Epidemiology - Erasmus MC - Publications 1998

Duijn CM van, Delasnerie-Lauprêtre N, Masullo C, Zerr I, Silva R de, Wientjes DPWM, Brandel J-P, Weber T, Bonavita V, Zeidler M, Alpérovitch A, Poser S, Granieri E, Hofman A, Will RG, for the European Union (EU) Collaborative Study Group of Creutzfeldt-Jakob disease (CJD). Case-control study of risk factors of Creutzfeldt-Jakob disease in Europe during 1993-95. Lancet 1998;351:1081-85.

Feenstra J, Drie-Pierik RJHM van, Laclé CF, Stricker BHCh. Acute myocardial infarction associated with sildenafil. Lancet 1998;352:957-8.

Klaver CCW, Assink JJM, Bergen AAB, Duijn CM van. Re: ABCR gene and age-related macular degeneration. Science 1998;279:1107.

Kors JA, Bruyne MC de, Hoes AW, Herpen G van, Hofman A, Bemmel JH van, Grobbee DE. T axis as an indicator of risk of cardiac events in elderly people. Lancet 1998;352:601-05.

Ott A, Slooter AJC, Hofman A, Harskamp F van, Witteman JCM, Broeckhoven C Van, Duijn CM van, Breteler MMB. Smoking and risk of dementia and Alzheimer's disease in a population-based cohort study: the Rotterdam Study. Lancet 1998;351:1840-3.

Uitterlinden AG, Burger H, Huang Q, Yue F, McGuigan FEA, Grant SFA, Hofman A, Leeuwen JPTM van, Pols HAP, Ralston SH. Relation of alleles of the collagen type 11 gene to bone density and the risk of osteoporotic fractures in postmenopausal women. N Engl J Med 1998;338:1016-21.

Visser LE, Stricker BHCh, Hoogendoorn M, Vinks A. Do not give paraffin to packers. Lancet 1998;352:1352-3.

Witteman JCM, Moerman CJ, Westendorp ICD. Re: Myth of the menopause paradox. Lancet 1998;352:407.

Epidemiology of diseases

Main participant(s):
Breteler Dr. M.M.B., Hofman Prof. Dr. A., Jong Prof. Dr. P.T.V.M. de, Witteman Dr. J.C.M.

General objectives:
This program includes scientific research in cardiovascular epidemiology, neuro-epidemiology and ophthalmologic epidemiology.

Cardiovascular epidemiologic research focusses on the determinants of atherosclerosis and coronary heart disease in the elderly, and on cardiovascular diseases in women. The research is based on the Rotterdam Study and it addresses inflammation markers and hemostasis as determinants of cardiovascular diseases in the elderly, and the effects of menopause, endogenous hormones and hormone replacement therapy in women.

Neuro-epidemiologic research focusses on the etiology of neurodegenerative and cerebrovascular diseases, including dementia and Alzheimer's disease, Parkinson's disease, stroke and cerebral white matter lesions. The research emphasizes the role of vascular factors in the etiology of these diseases, with use of state of the art neuro-imaging techniques (MRI, PET, TCD).

Ophthalmological epidemiologic research focusses on determinants of macula degeneration and glaucoma. The emphasis is on the putative role of genetic factors and vascular factors in the etiology of these diseases.

Key words:Atherosclerosis, Alzheimer's disease, cardiovascular diseases, cerebrovascular disorders, dementia, glaucoma, macular degeneration, Parkinson's disease, white matter lesions.

External cooperation:
Department of Medicine, University of Cambridge, UK
Channing Laboratory, Harvard University, Boston, USA
Dept of Epidemiology, Harvard University, Boston, USA
Dept of Medicine, Harvard University, Boston, USA
Heart, Lung and Blood Institute, NIH, Bethesda, USA
National Institute on Aging, NIH, Bethesda, USA
Division Genetic Epidemiology, Stanford University, California, USA
Sergievsky Center, Columbia University, New York, USA
Dept Epidemiology, Karolinska Institute, Stockholm, Sweden
Afdeling Klinische Epidemiologie, Academisch Ziekenhuis Leiden
Afdeling Klinische Epidemiologie & Biostatistiek, AMC, Amsterdam
Afdeling Epidemiologie & Gezondheidszorg, Universiteit Utrecht
Afdeling Medische Statistiek, Universiteit Leiden
RIVM, Bilthoven
Afdeling Epidemiologie, Nederlands Kankerinstituut
Afdeling Medische Statistiek, Universiteit Amsterdam
Onderafdeling Wiskunde, Technische Universiteit Eindhoven

Thesis - PUBLICATIONS 1^ST AUTHOR

E.B. Samrén
Maternal epilepsy and pregnancy outcome. A population-based study.
Erasmus University, April 15, 1998.

International scientific publications - PUBLICATIONS 1^ST AUTHOR

Bom JG van der, Maat MP de, Bots ML, Haverkate F, Jong PTVM de, Hofman A, Kluft C, Grobbee DE. Elevated plasma fibrinogen: cause or consequence of cardiovascular disease? Arterioscler Thromb Vasc Biol 1998;18:621-5.

Bots ML, Iglesias del Sol A, Grobbee DE. Carotid intima-media thickness in observational studies and intervention studies. Current Res Vascular Dis 1998;3:274-83.

Breteler MMB. Selegiline, or the problem of early termination of clinical trials (editorial). BMJ 1998;316:1182-3.

Bruyne MC de, Hoes AW, Kors JA, Dekker JM, Bemmel JH van, Grobbee DE. QTc dispersion predicts cardiac mortality in the elderly: the Rotterdam Study. Circulation 1998; 97:467-72.

Bruyne MC de, Kors JA, Visentin S, Herpen G van, Hoes AW, Grobbee DE, Bemmel JH van. Reproducibility of computerized ECG measurements and coding in a nonhospitalized elderly population. J Electrocardiol 1998; 3:189-95.

Claus JJ, Breteler MMB, Hasan D, Krenning EP, Bots ML, Grobbee DE, Swieten JC van, Harskamp F van, Hofman A. Regional cerebral blood flow and cerebrovascular risk factors in the elderly population. Neurobiol Aging 1998;19:57-64.

Claus JJ, Koning I de, Harskamp F van, Breteler MMB, Voet B, Gutzmann H, Dahlke F, Cammen T van der, Hofman A. Lisuride treatment of Alzheimer's disease. A preliminary placebo-controlled clinical trial of safety and therapeutic efficacy. Clin Neuropharmacol 1998;21:190-5.

Groot JC de, Leeuw FE de, Breteler MMB. Cognitive Correlates of Cerebral White Matter Changes. J Neural Transm 1998;53:41-67.

Ibrahim YWM, Bots ML, Mulder PGH, Grobbee DE, Hofman A, Jong PTVM de. Number of perifoveal vessels in aging, hypertension, and atherosclerosis: The Rotterdam Study. Invest Ophthalmol Vis Sci 1998;39:1049-53.

Iglesias del Sol A, Bots ML, Hoes AW, Grobbee DE. Common carotid intima-media thickness and risk of stroke. Cardiol Rev 1998;15:48-50.

Klaver CCW, Assink JJM, Bergen AAB, Duijn CM van. Re: ABCR gene and age-related macular degeneration. Science 1998;279:1107.

Klaver CCW, Kliffen M, Duijn CM van, Hofman A, Cruts M, Grobbee DE, Broeckhoven C van, de Jong PTVM. Genetic association of apolipoprotein E with age related macular degeneration. Am J Hum Genet 1998;63:200-6.

Klaver CCW, Wolfs RCW, Assink JJM, Duijn CM van, Hofman A, Jong PTVM de. Genetic risk of age-related maculopathy. Arch Ophthalmol 1998;116:1646-51.

Klaver CCW, Wolfs RCW, Vingerling JR, Hofman A, Jong PTVM de. Age-specific prevalence and causes of blindness and visual impairment in older population. Arch Ophthalmol 1998;116:653-58.

Klipstein-Grobusch K, Breeijen JH den, Goldbohm RA, Geleijnse JM, Hofman A, Grobbee DE, Witteman JCM. Dietary assessment in the elderly: validation of a semiquantitative food frequency questionnaire. Eur J Clin Nutr 1998;52:588-96.

Koning I de, Kooten F van, Dippel DWJ, Harskamp F van, Grobbee DE, Kluft C, Koudstaal PJ. The Camcog: A useful screening instrument for dementia in stroke patients. Stroke 1998; 29:2080-6.

Kors JA, Bruyne MC de, Hoes AW, Herpen G van, Hofman A, Bemmel JH van, Grobbee DE. T axis as an indicator of risk of cardiac events in elderly people. Lancet 1998;352:601-05.

Kors JA, Bruyne MC de, Hoes AW, Herpen G van, Hofman A, Bemmel JH van, Grobbee DE. T-loop morphology as a marker of cardiac events in the elderly. J Electrocardiol 1998; 31:54-9.

Launer LJ, Kalmijn S. Anti-oxidants and cognitive function: a review of clinical and epidemiologic studies. J Neural Transm 1998;53:1-8.

Meijer WT, Hoes AW, Rutgers D, Bots ML, Hofman A, Grobbee DE. Peripheral arterial disease in the elderly. The Rotterdam Study. Arterioscler Thromb Vasc Biol 1998;18:185-92.

Ott A, Breteler MMB, Harskamp F van, Stijnen T, Hofman A. Incidence and risk of dementia. The Rotterdam Study. Am J Epidemiol 1998;147:574-80.

Pleumeekers HJCM, Hoes AW, Mulder PGH, Does E van der, Hofman A, Laméris JS, Grobbee DE. Differences in observer variability of ultrasound measurements of the proximal and distal abdominal aorta. J Med Screening 1998; 5:104-8.

The Retinoschisis Consortium. Functional implications of the spectrum of mutations found in 234 cases with X-linked juvenile retinoschisis (XLRS). Human Molecular Genetics 1998;7;1185-92.

Vijver LPL van de, Kardinaal AFM, Duyvenvoorde W van, Kruijssen DACM, Grobbee DE, Poppel G van, Princen HMG. LDL oxidation and extent of coronary atherosclerosis. Arterioscler Thromb Vasc Biol 1998;18:193-9.

Witteman JCM, D'Agostino RB, Stijnen T, Kannel WB, Cobb JC, Ridder MAJ de, Hofman A, Robins JM. G-Estimation of causal effects: Isolated systolic hypertension and cardiovascular death in the Framingham Haert Study. Am J Epidemiol 1998; 148: 390-401.

Witteman JCM, Moerman CJ, Westendorp ICD. Re: Myth of the menopause paradox. Lancet 1998;352:407.

Wolfs RCW, Klaver CCW, Ramrattan RS, Duijn CM van, Hofman A, Jong PTVM de. Genetic risk of primary open angle glaucoma. Arch Ophthalmol 1998; 16:1640-5.

National scientific publications - PUBLICATIONS 1^ST AUTHOR

Bots ML, Elwood PC, Salonen JT, Nikitin Y, Koudstaal PJ, Grobbee DE, namens de EUROSTROKE-onderzoekers. Incidentie en risicofactoren voor ischemische en hemorrhagische beroerte in EUROPA; het EUROSTROKE project. Hart Bull 1998;29:40-5.

Bots ML, Grobbee DE. Quantitative B-mode ultrasound imaging in observational studies. In: Mercuri M, McPherson DD, Bassiouny H, Glagov S, eds. Non-invasive imaging of atherosclerosis. Kluwer Academic Publishers, Dordrecht, The Netherlands. 1998, 87-104.

Bots ML, Hoes AW, Koudstaal PJ, Hofman A, Witteman JCM, Grobbee DE. Verband tussen intima-mediadikte van de A. carotis communis en latere cardiovasculaire gebeurtenissen bij personen van 55 jaar en ouder uit het ERGO onderzoek. Ned Tijdschr Geneeskd 1998;142:1100-6.

Rutgers D, Meijer WT, Hoes AW, Bots ML, Hofman A, Grobbee DE. Prevalentie van perifere arteriële vaatziekte en claudicatio intermittens bij personen van 55 jaar en ouder: Het ERGO Onderzoek. Ned Tijdschr Geneesk 1998;142:2851-6.

Wilk EC van der, Bots ML, Koudstaal PJ, Hofman A, Grobbee DE. `Transient ischaemic attack' bij de algemene bevolking van 55 jaar of ouder: prevalentie en risicofactoren. Het ERGO onderzoek. Ned Tijdschr Geneeskd 1998;142:301-5.

Further scientific publications - PUBLICATIONS 1^ST AUTHOR

Bots ML, Iglesias del Sol A, Grobbee DE. Carotid intima-media thickness measurement: predictor of future cardiovascular disease. In: Reiber JHC, Van der Wall EE, eds. What is new in cardiovascular imaging. Kluwer Academic Publishers, 1998:391-400.

Breteler MMB. Risk factors for stroke in Alzheimer's disease. In: Leys D, Pasquier F, Scheltens Ph. Stroke and Alzheimer's disease. The Hague, The Netherlands, Holland Academic Graphics, 1998: page 59-70.

Launer LJ, Hoes AW. Nonsteroidal antiinflammatory drug use and the risk for Alzheimer's disease: weighing the epidemiologic evidence. In: Neurogeriatrics and Neurogerontology. Vol 2. Cacabelos, Winblad and Eidelenboom (eds) 1998: page 133-42.

International scientific publications- Publications co-author

Anderson DW, Rocca WA, Rijk MC de, Grigoletto F, Melcon MO, Breteler MMB, Maraganore DM. Case ascertainment uncertainties in prevalence surveys of Parkinson's disease. Movement Disorders 1998;13:626-32.

Brand E, Chatelain N, Keavney B, Caulfield M, Citterio L, Connell J, Grobbee DE, Schmidt S, Schunkert H, Schuster H, Sharma A, Soubrier F. Evaluation of the angiotensinogen locus in human essential hypertension: a European Study. Hypertension 1998;31:725-9.

Buijs PC, Krabbe-Hartkamp MJ, Bakker CJ, Lange EE de, Ramos LM, Breteler MMB, Mali WP. Effect of age on cerebral blood flow: measurement with ungated two-dimensional phase-contrast MR angiography in 250 adults. Radiology 1998;209:667-74.

Busschbach JJV, Rikken B, Grobbee DE, Charro FT De, Wit JM. Quality of life in short adults. Hormone Res 1998; 49:32-8.

Groeneveld FPMJ, Bareman FP, Barentsen R, Dokter HJ, Drogendijk AC, Hoes AW. Duration of hormonal replacement therapy in general practice; a follow-up study. Maturitas 1998; 29: 125-31.

Jonker C, Schmand B, Lindeboom J, Havekes LM, Launer LJ. Association between apolipoprotein E epsilon4 and the rate of cognitive decline in community-dwelling elderly individuals with and without dementia. Arch Neurol 1998;55:1065-9.

Kneyber MCJ, Brandenburg AH, Groot R de, Joosten KFM, Rotbarth PhH, Ott A, Steensel-Moll HA van. Risk factors for respiratory syncytial virus associated apnoea. Pneumology 1998;157:331-5.

Kooten F van, Bots ML, Breteler MMB, Haverkate F, Swieten JC van, Grobbee DE, Koudstaal PJ, Kluft C. The Dutch vascular factors in dementia study. rationale and design. J Neurol 1998;245:32-9.

Krabbe-Hartkamp MJ, Grond J van der, Leeuw FE de, Groot JC de, Algra A, Hillen B, Breteler MMB, Mali WP. Circle of Willis: morphologic variation on three-dimensional time-of-flight MR angiograms. Radiology 1998;207:103-11.

Robinson K, Arheart K, Refsum H, Brattström L, Boers G, Ueland P, Rubba P, Palma-Reis R, Meleady R, Daly L, Witteman JCM, Graham I. Low circulation folate and vitamin B₆ concentrations: risk factors for stroke, peripheral vascular disease and coronary artery disease. Circulation 1998;97:437-43.

Schmidt R, Hayn M, Reinhart B, Roob G, Schmidt H, Schumacher M, Watzinger N, Launer LJ. Plasma anti-oxidents and cognitive performance in the middle aged and elderly: Results of the Austrian Stroke Prevention Study. JAGS 1998;46:1407-10.

Terttu P, Deeg D. Bosscher R, Launer LJ Physical activity and self-rated health among 55-89 year old Dutch people. J Ag Heal 1998;10:311-26.

Tijmes NT, Bergen AAB, Jong PTVM de. Paucity of signs in X linked ocular albinism with a 700 kb deletion spanning the OA1 gene. BJO 1998;82:457-8.

Vaughan J, Durr A, Tassin J, Bereznai B, Gasser T, Bonifati V, Michele G De, Fabrizio E, Volpe G, Bandmann O, Johnson WG, Golbe LI, Breteler M, Meco G, Agid Y, Brice A, Marsden CD, Wood NW, European Consortium on Genetic Susceptibility in Parkinson's disease. The -synuclein Ala53Thr mutation is not a common cause of familial Parkinson's disease: a study of 230 European cases. Ann Neurol 1998;44:270-3.

Vaughan JR, Farrer MJ, Wszolek ZK, Gasser T, Durr A, Agid Y, Bonifati V, DeMichele G, Volpe G, Lincoln S, Breteler MMB, Meco G, Brice A, Marsden CD, Hardy J, Wood NW, The European Consortium on Genetic Susceptibility in Parkinson's Disease. Sequencing of the -synuclein gene in a large series of cases of familial Parkinson's disease fails to reveal any further mutations. Human Molecular Genetics 1998;7:751-3.

Veldink JH, Scheltens Ph, Jonker C, Launer LJ. Progression of cerebral white matter hypertensities on MRI is related to diastolic blood pressure. (Letter) Neurology 1998; 51:319-20.

Wiegersma PA, Hofman A, Zielhuis GA. The effect of school screening on surgery for adolescent idiopathic scoliosis. Eur J Public Health 1998;8:237-40.

National scientific publications - Publications co-author

Dam-Kuijpers AGE van, Zwan L van der, Bareman FP, Ponsioen BP, Hoes AW. Spirometrie in de huisartspraktijk: diagnostische informatie en haalbaarheid. Huisarts Wet 1998; 41: 286-9.

Hoying CB, Verezen CA, de Jong PTVM. Visuele rehalibitatie van patiënten met ouderdomsmaculadegeneratie. Ned Tijdschr Geneeskd 1998;142:164-9.

Kersseboom M, Hoes AW, Prins A. Recrutering en selectie in een huisartspraktijk van deelnemers aan een internationale hypertensietrial. Huisarts Wet 1998; 41: 561-4.

Walma EP, Hoes AW, Dooren C van, Prins A, Does E van der. Stoppen van langdurig diureticagebruik door ouderen: een kansrijke en veilige interventie. Een gerandomiseerde, placebogecontroleerde, dubbelblinde trial? Huisarts Wet 1998; 41: 480-5.

Basic epidemiologic research

Main participant(s):
Duijn Dr. C.M.van, Pols Prof. Dr. H.A.P., Sandkuijl L.J.

General objectives:
This program includes research in the fields of genetic epidemiology and endocrinologic epidemiology.

Genetic epidemiologic research aims at quantifying the population risk of disorders associated with genetic risk factors and at identifying new genetic factors involved in complex genetic disorders. For the empirical studies, the emphasis is on neurodegenerative and neurovascular disorders.

The work in endocrinological epidemiology focusses on the question whether circulating hormone levels are associated with incident diseases of the elderly and with parameters of frailty. The emphasis is on determinants of locomotor diseases (osteoporosis, osteoarthritis), and on sex hormones and thyroid hormones as determinants of disease.

Key words:Alzheimer's disease, endocrinological epidemiology, genetic epidemiology, sex hormones, thyroid hormones, Parkinson's disease, osteoporosis, osteoarthrosis.

External cooperation:see GZZ 640101

Thesis- PUBLICATIONS 1^ST AUTHOR

A.J.C. Slooter
The role of apolipoprotein E in atherosclerosis and dementia. An epidemiological approach to genetic susceptibility.
Erasmus University, September 9, 1998.

International scientific publications - PUBLICATIONS 1^ST AUTHOR

Burger H, Laet CEDH de, Daele PLA van, Weel AEAM, Witteman JCM, Hofman A, Pols HAP. Risk factors for increased bone loss in an elderly population: The Rotterdam Study . Am J Epidemiol 1998;147:871-9.

Fahim S, Duijn CM van, Baker FM, Launer L, Breteler MMB, Schudel WJ, Hofman A. A study of familial aggregation of depression, dementia and Parkinson's disease. Eur J Epidemiol 1998;14:233-8.

Kalmijn S, Launer LJ, Stolk RP, Jong FH de, Pols HAP, Hofman A, Breteler MMB, Lamberts SWJ. A prospective study on cortisol, dehydroepiandrosterone sulfate, and cognitive function in the elderly. J Clin Endocrinol Metab 1998;83:3487-92.

Laet CEDH de, Hout BA van, Burger H, Weel AEAM, Hofman A, Pols HAP. Hip fracture prediction in elderly men and women: validation in the Rotterdam study. J Bone Miner Res 1998;13:1587-93.

Odding E, Valkenburg HA, Algra D, Vandenouweland FA, Grobbee DE, Hofman A. Associations of radiological osteoarthritis of the hip and knee with locomotor disability in the Rotterdam Study. Ann Rheum Dis 1998;57:203-8.

Pols HAP, Uitterlinden AG, Leeuwen JPTM van. How about vitamin D receptor polymorphisms. Osteoporos Int 1998; 8;S20-S23.

Roks G, Cruts M, Bullido MJ, Backhovens H, Artiga MJ, Hofman A, Valdivieso F, Broeckhoven C van, Duijn CM van. The -491 A/T polymorphism in the regulatory region of the apolipoprotein E gene and early-onset Alzheimer's disease. Neurosci Lett 1998;258:65-8.

Slooter AJC, Cruts M, Kalmijn S, Hofman A, Breteler MMB, Broeckhoven Ch van, Duijn CM van. Risk estimates of dementia by Apolipoprotein E genotypes from a population-based incidence study: The Rotterdam Study. Arch Neurol 1998;55:964-8.

Slooter AJC, Duijn CM van, Bots ML, Ott A, Breteler MMB, Voecht J de, Wehnert A, Knijff P de, Havekes LM, Grobbee DE, Broeckhoven C van, Hofman A. Apolipoprotein E genotype, atherosclerosis, and cognitive decline: the Rotterdam Study. J Neural Transm Suppl 1998;53:17-29.

Slooter AJC, Knijff P de, Hofman A, Cruts M, Breteler MMB, Broeckhoven C Van, Havekes LM, Duijn CM van. Serum apolipoprotein E level is not increased in Alzheimer's disease: the Rotterdam Study. Neuroscience Letters 1998;248:21-4.

Uitterlinden AG, Huang Q, Pols HAP, Leeuwen JPTM van. Population analysis of the collagen type III 3' variable number of tandem repeat polymorphism by heteroduplex genotyping. Electrophoresis 1998;19:661-6.

National scientific publications - PUBLICATIONS 1^ST AUTHOR

Croes EA, Duijn CM van. De epidemiologie van prionziekten: de betekenis van fatale vouwfouten in de samenleving. In: P Borst, JJE van Everdingen, WA van Gool (eds); Vouwfouten: prionziekten als model. Boom, Belvedere, Amsterdam, Overveen, 1998, 15-25.

Duijn CM van. Epidemiologie van dementie. Diagnose Informatie en Medische Statistiek (DIMS) 1998;27:4-6.

International scientific publications- Publications Co-author

Cammen TJM van der, Verschoor CJ, Loon CPM van, Harskamp F van, Koning I de, Schudel WJ, Slooter AJC, Broeckhoven C van, Duijn CM van. Risk of left ventricular dysfunction in patients with probable Alzheimer's disease with APOE*4 allele. JAGS 1998;46:962-7.

Cras P, Harskamp F van, Hendriks L, Ceuterick C, Duijn CM van, Stefanko SZ, Hofman A, Kros JM, Broeckhoven Van C, Martin JJ. Presenile Alzheimer dementia characterized by amyloid angiopathy and large amyloid core type senile plaques in the APP 692AlaGly mutation. Acta Neuropathol 1998;96:253-60.

Cruts M, Duijn CM van, Backhovens H, Broeck M van den, Wehnert A, Serneels S, Sherrington R, Hutton M, Hardy J, St George-Hyslop PH, Hofman A, Broeckhoven C van. Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease. Hum Molec Genetics 1998;7:43-51.

Esch A, Steyerberg EW, Duijn CM van, Offringa M, Derksen-Lubsen G, Steensel-Moll HA. Prediction of febrile seizures in siblings: a practical approach. Eur J Pediatrics 1998;157:340-4.

Farrer LA, Duijn CM van, Mayeux R, Haines JL, Kukull WA, Hyman B, Pericak- Vance MA, Risch N. Effects of Age and Ethnicity on the link between APOE 4 and Alzheimer disease. JAMA 1998;279:581-2.

Huizenga NA, Koper JW, Lange P de, Pols HA, Stolk RP, Burger H, Grobbee DE, Brinkmann AO, Jong FH de, Lamberts SW. A polymorphism in the gluccocorticoid receptor gene may be associated with an increased sensitivity to glucocorticoids in vivo. J Clin Endocrinol Metab 1998; 83:144-51.

Huizenga NA, Koper JW, Lange P de, Pols HA, Stolk RP, Grobbee DE, Jong FH de, Lamberts SW. Interperson variability but intraperson stability of baseline plasma Cortisol concentrations, and its relation to feedback sensitivity of the hypothalamo pituitary adrenal axis to a low dose of dexamethasone in elderly individuals. J Clin Endocrinol Metab 1998; 83:47-54.

Janssen JAMJL, Burger H, Stolk RP, Grobbee DE, Jong FH de, Lamberts SWJ, Pols HAP. Gender-specific relationship between serum free and total IGF-I and bone mineral density in elderly men and women. Eur J Endocrin 1998;138:627-32.

Janssen JAMJL, Huizenga NATM, Solk RP, Grobbee DE, Pols HAP, Jong FH de, Attanasio AMF, Blum WF, Lamberts SWJ. The acute effect of dexamethasone on plasma leptin concentrations and the relationships between fasting leptin, the IGF-I/IGFB system, dehydroepiandrosterone, androstenedione and testosterone in an elderly population. Clin Endocrinol 1998; 48: 621-6.

Janssen JAMJL, Koper JW, Stolk RP, Englaro P, Uitterlinden AG, Huang Q, Leeuwen JPTM van, Blum WF, Attanasio AMF, Pols HAP, Grobbee DE, Jong FH de, Lamberts SWJ. Lack of associations between serum leptin, a polymorphism in the gene for the 3-adrenergic receptor and glucose tolerance in the Dutch population. Clin Endocrinol 1998;49:229-34.

Janssen JAMJL, Stolk RP, Pols HAP, Grobbee DE, Jong FH de, Lamberts SWJ. Serum free IGF-I, total IGF-I, IGFBP-1 and IFGBP-3 levels in an elderly population: relation to age and sex steroids levels. Clin Endocrinol 1998; 48:471-8.

Janssen JAMJL, Stolk RP, Pols HAP, Grobbee DE, Lamberts SWJ. Serum Total IGF-I, Free IGF-I, and IGFBP-1 levels in an elderly population, relation to cardiovasculair risk factors and disease. Arterioscler Thromb Vasc Biol 1998;18:277-82.

Meulenbelt I, Bijkerk C, Miedema H, Breedveld FC, Hofman A, Valkenburg HA, Pols HAP Slagboom PE, Duijn CM van. A genetic association study of the IGF-1 gene and radiological osteoarthritis in a population-based cohort study (the Rotterdam Study). Ann Rheum Dis 1998;57:371-4.

Stevens M, Duijn CM van, Kamphorst W, Knijff P de, Heutink P, Gool WA van, Scheltens Ph, Ravid R, Oostra BA, Niermeijer MF, Swieten JC van. Familial aggregation in fronto-temporal dementia. Neurology 1998;50:1541-5.

Will RG, Alperovitch A, Poser S, Pocchiari M, Hofman A, Mitrova E, Silva R de, D'Alesandro M, Brandel J-P, Zerr I, Duijn CM van. CreutzfeldtJakob disease in Europe 19931995. Descriptive epidemiology of Creutzfeld-Jakob disease in six European countries 1993-1995. For the EU Collaborative Study Group for CJD. Ann Neurol 1998;43:763-7

Clinical epidemiology

main participant(s) :
Hunink Prof. Dr. M.G.M., Krestin Prof. Dr. G.P., Stijnen Prof. Dr. Th., Stricker Dr. B.H.Ch.

General objectives:
This program comprises three parts: clinical epidemiology in collaboration with radiology, biostatistics, and pharmaco-epidemiology.

The clinical epidemiology group collaborates with the department of radiology in a joint research program for the Assessment of Radiological Technology (ART program). The program's research focusses on the assessment of medical imaging technology, especially diagnostic imaging but also image-guided therapies, with an emphasis on cardiovascular disease. Methodological research in the ART program focusses on developing the methods for evaluating diagnostic imaging procedures using stochastic modelling and utility assessement related to diagnostic testing and therapeutic outcomes.

The biostatistics group provides quantitative support for various studies in the Erasmus Medical Center Rotterdam. For its own research, the biostatistics group focusses on the application of new developments in statistics, such as new analytic methods for dependent observations, like random effect models, Baysian methods and sequential analysis.

Pharmaco-epidemiologic research focusses on unintended effects of medications, and the effects of medication use under common circumstances in large populations.

Key words:biostatistics, clinical epidemiology, diagnostic procedures, imaging techniques, pharmaco-epidemiology, prognostic factors, radiology, research methods.

External cooperation:see GZZ 640101

Thesis - PUBLICATIONS 1^ST AUTHOR

M.L.G. Janssen-Heijnen
Trends in lung cancer incidence and survival. Studies based on cancer registries.
Erasmus University, September 30, 1998.

International scientific publications - PUBLICATIONS 1^ST AUTHOR

Bijl AMH, Klauw MM van der, Vliet ACM van, Stricker BHCh. Anaphylactic reactions associated with trimethoprim. Clin Exp Allergy 1998;28:510-2.

Coebergh JWW, Janssen-Heijnen MLG, Razenberg PPA. Prevalence of co-morbidity in newly diagnosed cancer: a population-based study. Crit Rev Oncol Hematol 1998;27:97-100.

Coebergh JWW, Sant M, Berrino F, Verdecchia A. (guest editors). Survival of adult cancer patients in Europe diagnosed from 1978-1989: the Eurocare II study. Eur J Cancer 1998;34:2137-2138.

Dieleman JP, Veld BA in `t, Borleffs JCC, Schreij G. Acute respiratory failure associated with the human immunodeficiency virus (HIV) protease inhibitor indinavir in an HIV-infected patient. Clin Infect Dis 1998;26:1012-3.

Feenstra J, Drie-Pierik RJHM van, Laclé CF, Stricker BHCh. Acute myocardial infarction associated with sildenafil. Lancet 1998;352:957-8.

Feenstra J, Drie-Pierik RJHM van, Laclé CF, Stricker BHCh. Re: Acute myocardial infarction associated with sildenafil. Lancet 1998;352:1936-7.

Feenstra J, Grobbee DE, Jonkman FAM, Hoes AW, Stricker BHCh. Prevention of relapse in patients with congestive heart failure: the role of precipitating factors. Heart 1998;80:432-36.

Feenstra J, Veld BA in `t, Linden PD van der, Grobbee DE, Stricker BHCh. Risk factors for mortality in users of ibopamine. Br J Clin Pharmacol 1998; 46:71-7.

Houwing-Duistermaat JJ, Houwelingen HC van, Terhell A. Modelling the cause of dependency with application to filaria infection. Statist Med 1998;17:2939-54.

Houwing-Duistermaat JJ, Houwelingen HC van. Incorporation of family history in logistic regression models. Statist Med 1998;17:2865-82.

Hunink MGM, Bult JR, Vries JA de, Weinstein MC. Uncertainty in decision models analyzing cost-effectiveness: The joint distribution of incremental costs and effectiveness evaluated with a non-parametric bootstrap method. Med Decis Making 1998;18:337-46.

Hunink MGM. Special Issue Outcomes research and cost-effectiveness analysis in radiology (Editorial). Eur J Rad 1998;27:85-7.

Janssen-Heijnen MLG, Gatta G, Forman D, Capocaccia R, Coebergh JWW and the Eurocare Working Group. Variation in survival of patients with lung cancer in Europe, 1985-1989. Eur J Cancer 1998;34:2191-6.

Janssen-Heijnen MLG, Schipper RM, Klinkhamer PJ, Crommelin MA, Mooi W, Coebergh JWW. Divergent changes in survival for histological types of non-small cell lung cancer in the southeastern area of the Netherlands, since 1975. Br J Cancer 1998;77:2053-57.

Janssen-Heijnen MLG, Schipper RM, Klinkhamer PJJM, Crommelin MA, Coebergh JWW. Improvement and plateau in survival of small-cell lung cancer, since 1975: a population-based study. Ann Oncology 1998;9:543-7.

Janssen-Heijnen MLG, Schipper RM, Razenberg PPA, Crommelin MA, Coebergh JWW. Prevalence of co-morbidity in lung cancer patients and its relation to treatment: a population-based study. Lung Cancer 1998;21:105-13.

Klauw MM van der, Wilson JHP, Stricker BHCh. Drug-associated agranulocytosis: 20 years of reporting in The Netherlands (1974-1994). Am J Hematology 1998;57:206-11.

Launer JL, Veld in 't BA. NSAIDs and Alzheimer's disease: contribution of observational epidemiologic studies. Neurobiol Aging 1998:19;617-618.

Li X, Xu Z, Hofman A. Epidemiology and cost-effectiveness analysis of hepatitis A in Liuzhou city. Chin J Epidemiol 1998; 19:93-96.

Linden PD van der, Lei J van der, Vlug AE, Stricker BHCh. Skin reactions to antibacterial agents in general practice. J Clin Epidemiol 1998;51:703-8.

Ottervanger JP, Valkenburg HA, Grobbee DE, Stricker BHCh. Differences in perceived and presented adverse reactions to drugs in general practice. J Clin Epidemiol 1998;51:795-9.

Post PN, Damhuis RAM, van der Meijden APM. Variation in survival of patients with prostate cancer in Europe since 1978. Eur J Cancer 1998;34:2226-31.

Post PN, Kil PJM, Schapers RF, Crommelin MA, Coebergh JWW. Trends in incidence of prostate cancer in an unscreened Dutch population, 1971-1994. Eur J Cancer 1998;34:755-9.

Sjahid SI, Linden PD van der, Stricker BHCh. The agreement between the pharmacy medication history and patient interview for cardiovascular drugs: the Rotterdam elderly study. Br J Clin Pharmacol 1998;45;591-5.

Stricker BHCh. Anaphylaxis. Epidemiology 1998;9:114-16.

Veld in 't BA, Launer LJ, Hoes AW, Ott A, Hofman A, Breteler MMB, Stricker BHCh. NSAIDs and incident Alzheimer's disease. The Rotterdam Study. Neurobiol Aging 1998;19:607-11.

Visser LE, Stricker BHCh, Hoogendoorn M, Vinks A. Do not give paraffin to packers. Lancet 1998;352:1352-3.

Westendorp ICD, Ankum WM, Mol BWJ, Vonk J. Prevalence of Asherman's syndrome after secondary removal of placental remnants or a repeat currettage for incomplete abortion. Human Reproduction 1998;13:3347-50.

National scientific publications - PUBLICATIONS 1^ST AUTHOR

Bosch JL, Hammitt JK, Weinstein MC, Hunink MGM. Estimating general-population utilities using one binary gamble question per respondent. Med Decis Making 1998; 18: 381-90.

Bosch JL, Tetteroo E, Mali WPTM, Hunink MGM for the Dutch Iliac Stent Trial Study Group. Iliac arterial occlusive disease: Cost-effectiveness analysis of stent placement versus percutaneous transluminal angioplasty. Radiology 1998; 208:641-8

Coebergh JWW (boekbespreking Cancer Wars door Robert Proctor) Blootstelling aan kankerverwekkende stoffen. Tijdschr Kanker 1998;22:6-7.

Coebergh JWW (boekbespreking) Cancer Epidemiology and Prevention (Schottenfeld D, Fraumeni JF, red.) Tijdschr Kanker 1998;22:34-5.

Coebergh JWW (boekbespreking) Cancer Epidemiology and Prevention (Schottenfeld D, Fraumeni JF, red.) Ned Tijdschr Geneeskd 1998;142:1743.

Coebergh JWW. Schijn bedriegt in clusteronderzoek van kanker. Ned Tijdschr Geneeskd 1998;142:1542-5.

Coebergh JWW. Epidemiologie van kanker. In: Nascholing Oncologie. Curacao, 1998, pp. 32-6.

Dieleman JP, Hillebrand-Haverkort ME, Ende ME van de, Sturkenboom MCJM, Lange JMA, Stricker BHCh. Lipodystrofie en 'buffalo hump' bij de behandeling met HIV-proteaseremmers. Ned Tijdschr Geneeskd 1998;142:2856-60.

Dieleman JP, Sturkenboom MCJM, Stricker BHCh. Driejarig onderzoek naar veiligheid van HIV-proteaseremmers. Landelijk cohortonderzoek volgt 2.500 patiënten. Pharm Weekbl 1998;133:568-71.

Eland IA, Gooyer DJ de, Stokkers P, Westereveld BD, Wilson JHP, Stricker BHCh. Acute pancreatitis toegeschreven aan het gebruik van mesalazine. Ned Tijdschr Geneeskd 1998;54:417-20.

Eland IA, Kerkhof SCMB, Overbosch D, Wismans PJ, Stricker BHCh. Cholestatische hepatitis toegeschreven aan het gebruik van tiabendazol. Ned Tijdschr Geneeskd 1998;142:1331-4.

Eland IA, Otter R, Krommendijk R, Stricker BHCh. Verstrekking van taxoïden in 1996: ongelijkheid van zorg. Ned Tijdschr Geneeskd 1998;142:518-21.

Feenstra J, Borst F, Huige MC, Oei SG, Stricker BHCh. Acuut myocardinfarct na toediening van sulproston. Ned Tijdschr Geneeskd 1998;142:192-5.

Feenstra J, Grootheest AC van, Stricker BHCh. Bijwerkingen van cardiovasculaire geneesmiddelen in de huisartsenpraktijk: de farmacotherapeutische behandeling van chonisch hartfalen. Hartbulletin 1998;29:198-203.

Hansen B, Man RA de. Het effect van interferon alfa op het ontstaan van hepatocellulair carcinoom bij patienten met virale hepatitis en cirrose. Ned Tijdschr Geneeskd 1998;142:2641.

Heeringa M, Honkoop P, Man RA de, Feenstra J, Smits CMH. Ernstige psychiatrische bijwerkingen van interferon alfa-2b. Ned Tijdschr Geneeskd 1998;142:1618-21.

Janssen-Heijnen MLG, Coebergh JWW. Epidemiologie van longtumoren en mesothelioom: veranderingen in incidentie en overleving. Rotterdam: Integraal Kankercentrum Rotterdam, 1998:3-5.

Klauw MM van der, Wilson JHP, Stricker BHCh. Anafylaxie toegeschreven aan geneesmiddelengebruik. 20 jaar meldingen in Nederland (1974-1994) en overzicht van de literatuur. Pharm Weekbl 1998;133:1174-82.

Ottervanger JP, Hoorntje JCA, Valkenburg HA, Grobbee DE, Stricker BHCh. Exercise testing in patients with chest pain to sumatriptan. Neth J Med 1998;53:245-8.

Puijenbroek EP van, Feenstra J, Meyboom RHB. Verstoring van de pilcyclus tijdens het gelijktijdig gebruik van itraconazol en orale anticonceptiva. Ned Tijdschr Geneeskd 1998;142:146-9.

Puijenbroek EP van, Metselaar HJ, Berghuis PHE, Zondervan PE, Stricker BHCh. Acute levernecrose bij gebruik van ketoconazol tijdens de behandeling van onychomycose. Ned Tijdschr Geneeskd 1998;142:2416-8.

Riemsdijk MM van, Stricker BHCh. Bijwerkingen van malariaprofylaxe. Modern Medicine 1998;22:65-68.

Veld BA in `t, Kwee-Zuiderwijk WJM, Puijenbroek EP van, Stricker BHCh. Neuropsychiatrische bijwerkingen toegeschreven aan het gebruik van oxybutynine. Ned Tijdschr Geneeskd 1998;142:590-2.

Visser LE, Does JA van der, Poel CL van der, Stricker BHCh. Hemovigilantie. Pharm Weekbl 1998;133:1002-7

Further scientific publications - PUBLICATIONS 1^ST AUTHOR

Coebergh JWW, Does - van den Berg A van der, Heijden LH van der, Kamps WA, Otter R, Schouten LJ. Registries of childhood cancer in the Netherlands: Dutch Childhood Leukaemia Study Group, 1973-1992; Netherlands Cancer Registry, 1989-1992; Eindhoven Cancer Registry, 1973-1992. in: Trends in incidence of childhood cancer. Parkin DM, Stiller C, Young J, (eds.) Lyon: IARC Scientific Publications, No. 144, 1998, pp. 315-318

International scientific publications- Publications co-author

Alers JC, Krijtenburg PJ, Hop WCJ, Bolle WABM, Schroder FH, Kwast TH van der, Bosman FT, Dekken H van. Longitudinal evaluation of cytogenetic aberrations in prostatic cancer: tumours that recur in time display an intermediate genetic status between non-persistent and metastatic tumours. J Pathology 1998; 185: 273-83.

Alexander FE, Boyle P, Carli PM, Coebergh JWW, Draper GJ, Ekbom A, Levi F, McKinney PA, McWhirter W, Michaelis J, Prastard C, Peris-Bonet R, Petrodou E, Pukkala E, Olsen JH, Vatten L, Wray N on behalf of the Euroclus project. Spatial and temporal patterns in childhood leukaemia: further evidence for an infectious origin. Br J Cancer 1998;77:812-17.

Alexander FE, Wray N, Boyle P, Carli PM, Coebergh JWW, Draper GJ, Ekbom A, Levi F, McKinney PA, McWhirter W, Michaelis J, Prastard C, Peris-Bonet R, Petrodou E, Pukkala E, Olsen JH, Vatten L, on behalf of the Euroclus project. Spatial clustering of childhood leukaemia: summary results from the Euroclus project. Br J Cancer 1998;77:818-24.

Bakker J, Overhagen H van, Wielenga J, Marie S de, Nouwen J., Ridder M de, Laméris J. Infectious Complications of Radiologically Inserted Hickman Catheters in Patients with Hematologic Disorders. Cardiovasc Intervent Radiol 1998; 21:116-21.

Berger RMF, Bolraap G, Hop WCJ, Bogers AJJC, Hess J. Heparin as a risk factor for perigraft seroma complicating the modified Blalock-Taussig shunt. J Thoracic Cardiovasc Surg 1998; 116: 286-92.

Blom HM, Godthelp T, Fokkens WJ, Kleinjan A, Mulder PG, Rijntjes E. The effect of nasal steroid aqueous spray on nasal complaint scores and cellular infiltrates in the nasal mucosa of patients with nonallergic, noninfectious perennial rhinitis [comments]. J Allergy Clin Immunol 1998; 102: 155-6.

Blom HM, Severijnen LAWFM, Rijswijk JB van, Mulder PGH, Gerth van Wijk R, Fokkens WJ. The long-term effects of capsaicin aqueous spray on the nasal mucosa. Clin and Exp Allergy 1998; 28: 1351-8.

Bosch WA van den, Rosman M, Stijnen T. Involutional lower eyelid entropin: results of a combined approach. Ophtalmic Surgery Lasers 1998;29:581-6.

Braat JPM, Mulder PG, Fokkens WJ, Gerth van Wijk R, Rijntjes E. Intranasal cold dry air is superior to histamine challenge in determining the presence and degree of nasal hyperreactivity in nonalergic noninfectious perennial rhinitis. Am J Respir Crit Care Med 1998; 157: 1748-55.

Briel JW, Boer LM de, Hop WCJ, Schouten WR. Clinical outcome of anterior overlapping external anal sphincter repair with internal anal sphincter imbrication. Dis Colon Rectum 1998; 41: 209-14.

Brouwer JT, Nevens F, Kleter B, Elewaut A, Adler M, Brenard R, Chamuleau RA, Michielsen PP, Pirotte J, Hautekeete ML, Weber J, Bourgeois N, Hansen BE, Bronkhorst CM, ten Kate FJ, Heijtink RA, Fevery J, Schalm SW. Efficacy of interferon dose and prediction of response in chronic hepatitis C: Benelux study in 336 patients. J Hepatol 1998;28:951-9.

Bruijn JA, Moleman P, Mulder PG, Broek WW van den. Comparison of 2 treatment strategies for depressed inpatients: imipramine and lithium addition or mirtazapine and lithium addition. J Clin Psychiatry 1998; 59: 657-63.

Bruin NC de, Degenhart HJ, Gal S, Westerterp KR, Stijnen T, Visser HKA. Energy utilization and growth in breast-fed and formula-fed infants measured prospectively during the first year of life. Am J Clin Nutrition 1998;67:885-96.

Bucx MJL, Snijders CJ, Vegt MH van der, Stijnen T. An evaluation of a modified Macintosh laryngoscope in a maniken. Can J Anaestisia 1998;45:483-7.

Bult JR, Hunink MGM, Tsevat J, Weinstein MC. Heterogeneity in the relationship between the time trade-off and Short Form-36 for HIV-infected and primary care patients. Medical Care 1998; 36: 523-32.

Carli PM, Coebergh JWW, Verdecchia A, and the Eurocare Working Group. Variation in survival of adult patients with haematological malignancies in Europe, since 1978. Eur J Cancer 1998;34:2253-63.

Cobbaert C, Mulder P. Regional serum cholesterol differences in Belgium: do genetically determined cardiovascular risk factors contribute? Int J Epidemiol 1998; 27: 605-13.

Dijk APM van, Meijssen MAC, Brouwer AJBW, Hop WCJ, Bergeijk JD van, Feyerabend C, Wilson JHP, Zijlstra FJ. Transdermal nicotine inhibits interleukin 2 systhesis by mononuclear cells derived from healthy volunteers. Eur J Clin Invest 1998; 28: 664-71.

Dongen JJM van, Seriu T, Panzer-Grumayer ER, Biondi A, Pongers-Willemse MJ, Corral L, Stolz F, Schrappe M, Masera G, Kamps WA, Gadner H, Wering ER van, Ludwig WD, Basso G, Bruijn MAC de, Cazzaniga G, Hettinger K, Does-van den Berg A van der, Hop WCJ, Riehm H, Bartram CR. Prognostic value of minimal residual disease in childhood acute lymphblastic leukemia; a prospective study of the international BFM study group. Lancet 1998; 352: 1731-8.

Ent CK van der, Grinten CP van der, Meessen NE, Luijendijk SC, Mulder PG, Bogaard JM. Time to peak tidal expiratory flow and the neuromuscular control of expiration. Eur Respir J 1998; 12: 646-52.

Fleischmann KE, Hunink MGM, Kuntz KM, Douglas PS. Exercise echocardiography or exercise SPECT imaging? A meta-analysis of diagnostic test performance. JAMA 1998; 280: 913-20.

Genderen PJ van, Prins FJ, Lucas IS, Moesdijk D van de, Vliet HH van, Strik R van, Michiels JJ. Decreased half-life time of plasma von Willebrand factor collagen binding activity in essential thrombocythaemia: normalization after cytoreduction of the increased platelet count. Br J Haematol 1997; 99:832-6. (delayed).

Geus WP, Mulder PGH, Nicolai JJ, Boomgaard DM van den. Acid-inhibitory effects of omeprazole and lansoprazole in helicobacter pylori-negative healthy subjects. Aliment Pharmacol Ther 1998; 12: 329-35.

Groeneweg M, Quero JC, Bruijn I de, Hartmann IJC, Essink-Bot ML, Hop WCJ, Schalm SW. Subclinical hepatic encephalopathy impairs daily functioning. Hepatology 1998; 28:45-9.

Haensel SM, Klem TMAL, Hop WCJ, Slob AK. Fluoxetine and premature ejaculation: a double blind crossover, placebo-controlled study. J Clin Psychopharmacology 1998; 18: 72-7.

Hagen EC, Daha MR, Hermans J, Andrassy K, Csernok E, Gaskin G, Lesavre P, Lüdemann J, Rasmussen N, Sinico RA, Wiik A, Woude FJ van der. Diagnostic value of standardized assays for anti-neutrophil cytoplasmic antibodies in idiopathic systemic vasculitis. Kidney Int 1998;53:743-53.

Hazelzet JA, Groot R de, Mierlo G van, Joosten KF, Voort E van der, Eerenberg A, Stuur MH, Hop WCJ, Hack CE. Complement activation in relation to capillary leakage in children with septic shock and purpura. Infect Immun 1998; 66: 5350-60.

Heerdink ER, Leufkens HG, Herings RMC, Ottervanger JP, Stricker BHCh, Bakker A. NSAIDs associated with increased risk of congestive heart failure in elderly patients taking diuretics. Arch Intern Med 1998;158;1108-12.

Hoed PT den, Boelhouwer RU, Veen HF, Hop WCJ, Bruining HA. Infections and bacteriological data after laparoscopic and open galbladder surgery. J Hosp Infection 1998;39:27-37.

Hoekstra MO, Grol MH, Hovenga H, Bouman K, Stijnen T, Koëter GH, Gerritsen J, Kaufman HF. Eosinophil and mast cell parameters in children with stable moderate asthma. Pediatr Allergy Immunol 1998; 9:143-9.

Holm AF, Fokkens WJ, Godthelp T, Mulder PGH, Vroom ThM, Rijntjes E. A 1-year placebo-controlled study of intranasal Fluticasone Propionate Aqueous Nasal Spray in patients with perennial allergic rhinitis: a safety and biopsy study. Clin Otolaryngol 1998; 23: 69-73.

Hoogstraten HJF van, Smet MBM de, Renooij W, Breed JGS, Engels LGJB, Ouden-Muller JW den, Rijk MCM, Smit AM, Zwertbroek R, Hop WCJ, Berge Henegouwen GP van, Schalm SW, Buuren HR van. A randomized trial in primary biliary cirrhosis comparing ursodeoxycholic acid in daily doses of either 10 mg/kg or 20 mg/kg. Aliment Pharmacol Ther 1998; 12: 965-71.

Hoogstraten HJF van, Wolfhagen FHJ, Meeberg PC van de, Kuiper H, Nix GAJJ, Becx MCJM, Hoek AC, Houte DPF van, Rijk MCM, Salemans JMJI, Scherpenisse J, Schrijver M, Smit AM, Spoelstra P, Stadhouders PHGM, Yan TG, Hop WCJ, Tenkate FJW, Berge-Henegouwen GP van, Schalm SW, Buuren HR van. Ursodeoxycholic acid therapy for primary sclerosing cholangitis: results of a 2-year randomized controlled trial to evaluate single versus multiple daily doses. J Hepatology 1998; 29: 417-23.

Idu MM, Buth J, Cuypers P, Hop WCJ, Pavoordt EDWM van de, Tordoir JMH. Economizing vein-graft surveillance programs. Eur J Vasc Endovasc Surg 1998; 15: 432-8.

Idu MM, Buth J, Hop WCJ, Cuypers P, Pavoordt EDWM van de, Tordoir JMH. Vein graft surveillance: is graft revision without angiography justified and what criteria should be used? J Vasc Surg 1998; 27: 399-411.

Jansen RMG, Vries SO de, Cullen KA, Donaldson MC, Hunink MGM. Cost-identification analysis of revascularization procedures in patients with peripheral arterial occlusive disease. J Vasc Surg 1998; 28: 617-23.

Jobsis Q, Raatgeep HC, Schellekens SL, Hop WCJ, Hermans PWM, Jongste JC de. Hydrogen peroxide in exhaled air of healthy children: reference values. Eur Resp J 1998; 12: 483-5.

Kaam AHLC van, Beek RHT van, Vergunst-van Keulen JG, Heijden J van der, Lutz-Dettinger N, Hop W, Sauer PJJ. Fibre optic versus conventional phototherapy for hyperbilirubinaemia in preterm infants. Eur J Pediatr 1998; 157: 132-7.

Kamphuisen PW, Houwing-Duistermaat JJ, Houwelingen HC van, Eikenboom JCJ, Bertina RM, Rosendaal FR. Familial clustering of factor VIII and Willebrand factor levels.Thromb Haemost 1998;79:323-7.

Klerk LWL de, Fontijne WPJ, Stijnen T, Braakman R, Tange HLJ, Linge B van. Spontaneous remodeling of the spinal canal after conservative management of thoracolumbar burst fractures. Spine 1998;23:1057-60.

Kleter B, Brouwer JT, Nevens F, Doorn LJ van, Elewaut A, Versieck J, Michielsen PP, Hautekeete ML, Chamuleau RAFM,Brenard R, Bourgeois N, Adler M, Quint WGV, Bronkhorst CM, Heijtink RA, Hop WCJ, Fevery J, Schalm SW. Hepatitis C virus genotypes: epidemiological and clinical associations. Liver 1998; 18: 32-8.

Klijn AJ, Hop WCJ, Mickisch G, Schroder FH, Bosch JLHR. The artificial urinary sphincter in men incontinent after radical prostatectomy: 5 year actuarial adequate function rates. Br J Urol 1998; 82: 530-3.

Kuijpens JL, Hansen B, Hamming JF, Ribot JG, Haak HR, Coebergh J-WW. Trends in treatment and long-term survival of thyroid cancer in Southeastern Netherlands, 1960-1992. Eur J Cancer 1998;34:1235-41.

Laudy JAM, Janssen MMM, Struyk PC, Stijnen T, Wallenburg HCS, Wladimiroff JW. Fetal liver volume measurement by three-dimensional ultrasonography: a preliminary study. Ultrasound Obstet Gynecol 1998:12:93-6.

Laudy JAM, Janssen MMM, Struyk PC, Stijnen T, Wladimiroff JW. Three-dimensional ultrasonography of normal fetal lung volume: a preliminary study. Ultrasound Obstet Gynecol 1998:11:13-6.

Leenders ACAP, Daenen S, Jansen RLH, Hop WCJ, Lowenberg B, Wijerman PW, Cornelissen J, Herbrecht R, Lelie H van der, Hoogsteden HC, Verbrugh HA, Marie S de. Liposomal amphotericin B compared with amphotericin B deoxycholate in the treatment of documented and suspected neutropenia-associated invasive fungal infections. Br J Haematology 1998; 103: 205-12.

Li Jiong, Berrino F, Coebergh JWW and the Eurocare Working Group. Variation in survival for adults with nasopharyngeal cancer in Europe, 1978-89. Eur J Cancer 1998;34:2162-6.

Lugt A van der, Gussenhoven EJ, Pasterkamp G, Stijnen T, Reekers JA, Berg FG van den, Tielbeek AV, Seelen JL, Pieterman H. Intravascular ultrasound predictors of restenosis after balloon angioplasty of the femoropopliteal artery. Eur J Endovasc Surg 1998; 16: 110-9.

Luiten EJT, Hop WCJ, Endtz HP, Bruining HA. Prognostic importance of gram-negative intestinal colonization preceding pancreatic infection in severe acute pancreatitis. Intensive Care Med 1998; 24: 438-45.

Lybeert MLM, Putten WLJ van, Brölmann HAM, Coebergh JWW. Postoperative radiotherapy in patients with endometrial carcinoma stage I. Wide variation in referral patterns, but no effect on long-term survival in a retrospective study in the Southeast Netherlands. Eur J Cancer 1998;34:586-90.

Macklon NS, Hop WCJ, Wladimiroff JW. Fetal cardiac function and septal thickness in diabetic pregnancy: a controlled observational and reproducibility study. Br J Obstet Gynaec 1998; 105: 661-6.

Meier CR, Sturkenboom MCJM, Cohen AS, Jick H. Postmenopausal estrogen replacement therapy and the risk of developing systemic lupus erythematosus or discoid lupus. J Rheumatol 1998;25:1515-9.

Moll van Charante AW, Groen J, Mulder PGH, Rijpkema SGT, Osterhaus ADME. Occupational risks of zoonotic infections in Dutch forestry workers and muskrat catchers. Eur J Epidemiol 1998; 14: 109-16.

Moll van Charante AW, Mulder PG. Reporting of industrial accidents in The Netherlands. Am J Epidemiol 1998; 148:182-90.

Ouden D van den, Hop WCJ, Schroder FH. Progression in and survival of patients with locally advanced prostate cancer (T3) treated with radical prostatectomy as monotherapy. J Urol 1998; 160: 1392-7.

Ouden D van den, Kranse R, Hop WCJ, Kwast Th van der, Schroder FH. Microvascular invasion in prostate cancer: prognostic significance in patients treated by radical prostatectomy for clinically localized carcinoma. Urol Int 1998; 60: 17-24.

Pierik FH, Vreeburg JTM, Stijnen T, Jong FH de, Weber RFA. Serum inhibin as a marker of spermatogenesis. J Clin Endocrinol Metab 1998; 83: 3110-4.

Pierik FH, Vreeburg JTM, Stijnen T, Roijen JH van, Dohle GR, Lameris JS, Timmers T, Weber RFA. Improvement of sperm count and motility after litigation of varicoceles detected with color Doppler ultrasonography. Andrology 1998; 21: 256-60.

Rijnsoever EW van, Kwee-Zuiderwijk WJM, Feenstra J. Angioneurotic edema attributed to the use of losartan. Arch Int Med 1998;158:2063-5.

Robben SGF, Meradji M, Diepstraten AFM, Hop WCJ. US of the painfull hip in childhood: diagnostic value of cartilage thickening and muscle atrophy in the detection of Perthes disease. Radiology 1998; 208: 35-42.

Sanden GA van der, Schouten LJ, Dijck JA van, Andel JP van, Coebergh JWW. Incidence of primary central nervous system cancers in South and East Netherlands in 1989-1994. Neuroepidemiology 1998;17:247-57.

Sanden GAC van der, Wesseling P, Schouten LJ, Teepen HL, Coebergh JWW. A uniform histological cluster scheme for ICD-O coded primary central nervous system tumors. Neuroepidemiology 1998;17:233-46.

Sanden van der GAC, Schouten LJ, Coebergh JWW. Incidence of primary cancer of the central nervous system in southeastern Netherlands during the period 1980-94. Cancer Causes Control 1998;9:225-8.

Sant M, Capocaccia R, Verdecchia A, Esteve J, Gatta G, Micheli A, Coleman M, Berrino F, and the Eurocare Working Group. Survival of women with breast cancer in Europe: variation with age, year of diagnosis and country. Int J Cancer 1998;77:679-83.

Schipper I, Hop WCJ, Fauser BCJM. The follicle-stimulating hormone (FSH) threshold/window concept examined by different interventions with exogeneous FSH during the follicular phase of the normal menstrual cycle: duration, rather than magnitude, of FSH increase affects follicular development. J Clin Endocrinology Metabolism 1998; 4: 1292-8.

Siersema PD, Hop WCJ, Dees J, Tilanus HW, Blankenstein M van. Coated self-expanding metal stents versus latex prostheses for esophagogastric cancer with special reference to prior radiation and chemotherapy: a controlled prospective study. Gastrointest Endosc 1998; 47: 113-20.

Slob AK, Lottman PEM, Hop WCJ, Incrocci L, Werff ten Bosch JJ van der. Diagnosis and treatment of erectile dysfunction in retrospect. Sexual Dysfunction 1998; 1: 43-7.

Slob AK, Steyvers CL, Lottman PEM, Werff ten Bosch JJ van der, Hop WCJ. Routine psychophysiological screening of 384 men with erectile dysfunction. J Sex Marital Therapy 1998; 24: 273-279.

Splunder P van, Stijnen T, Wladimiroff JW. Fetal atrioventricular, venous, and arterial flow velocity waveforms in small for gestational age fetus. Pediatric Research 1997;42:765-75. (delayed)

Spronsen DJ van, Post PN, Crommelin MA, Breed WPM, Coebergh JWW. Modest decline in late mortality following Hodgkin's disease in the southeastern Netherlands since 1972. Ann Hematol 1998;76:205-9.

Stam H, Beek A van der, Grünberg K, Ridder MAJ de, Jongste JC de, Versprille A. A Rebreathing Method to Determine Carbon Monoxide Diffusing Capacity in Children: Reference Values for 6 to 18 year-olds and Validation in Adults Volunteers. Pediatr Pulmonol 1998; 25:205-12.

Tetteroo E, Graaf Y van der, Bosch JL, Engelen AD van, Hunink MGM, Mali WPTM for the Dutch Iliac Stent Trial Study Group. Randomised comparison of primary stent placement versus primary angioplasty followed by selective stent placement in patients with iliac-artery occlusive disease. Lancet 1998; 351: 1153-9.

Ursem NTC, Struijk PC, Hop WCJ, Clark EB, Keller BB, Wladimiroff JW. Heart rate and flow velocity variability as determined from umbilical Doppler velocimetry at 10-20 weeks of gestation. Clinical Science 1998; 95: 539-45.

Ursem NTC, Brinkman HJF, Struijk PC, Hop WCJ, Kempski MH, Keller BB, Wladimiroff JW. Umbilical artery waveform analysis based on maximum, mean and mode velocity in early human pregnancy. Ultrasound Med Biol 1998; 24: 1-7.

Ursem NTC, Kempski MH, Ridder MAJ de, Clark EB, Wladimiroff JW. An estimate of fetal autonomic state by spectral analysis of human umbilical artery flow velocity waveforms. Cardiovascular Research 1998;37:601-5.

Veen AH van der, Geel AN van, Hop WCJ, Wiggers T. Median sternotomy: the preferred incision for resection of lung metastases. Eur J Surgery 1998; 164: 507-12.

Verwey PJM, Houwelingen JC van, Stijnen T. A goodness of fit test for Cox's proportional hazards model based on martingale residuals. Biometrics 1998;54:147-56.

Vleeming W, Amsterdam JGC van, Stricker BHCh, Wildt DJ de. A review of ACE-inhibitor-induced angioedema. Drug Safety 1998;18:171-88.

Vries SO de, Donaldson MC, Hunink MGM. Contralateral symptoms after unilateral intervention for peripheral arterial occlusive disease. J Vasc Surg 1998; 27: 414-21.

Vries SO de, Fidler V, Kuipers W, Hunink MGM. Fitting multi-state transition models with autoregressive logistic regression: supervised exercise in intermittent claudication. Med Decis Making 1998; 18: 52-60.

Vries SO de, Kuipers W, Hunink MGM. Intermittent claudication: symptom severity vs. health values. J Vasc Surg 1998; 27: 422-30.

Waard-van der Spek FB de, Elst EF, Mulder PG, Munte K, Devillers AC, Oranje AP. Diagnostic tests in children with atopic dermatitis and food allergy. Allergy 1998; 53: 1087-91.

Waard-van der Spek FB de, Oranje A, Mulder PG, Bernsen JC, Kleij-Troost BW van der, Berg J van den. Emla cream as a local anaesthetic in NMR vaccination [letter]. Int J Clin Pract 1998; 52: 136.

Weijerman PC, Schurmans JR, Hop WCJ, Schroder FH, Bosch JLHR. Morbidity and quality of life in patients with orthotopic and heterotopic continent urinary diversion. Urology 1998; 51: 51-6.

Weststrate JTM, Hop WCJ, Aalbers AGJ, Vreeling AWJ, Bruining HA. The clinical relevance of the Waterlow pressure sore risk scale in the ICU. Intensive Care Med 1998; 24: 815-20.

Wijck EEE van, Bosch JL, Hunink MGM. Time trade-off values and standard gamble utilities assessed during telephone interviews versus face-to-face interviews. Med Decis Making 1998; 18: 400-5.

Winden CMQ van, Visser A, Hop W, Sterk PJ, Beckers S, Jongste JC de. Effects of flutter and PEP mask on symptoms and lung function in children with cystic fibrosis. Eur Resp J 1998; 12: 143-7.

Wolfhagen FHJ, Hoogstraten HJF, Buuren HR van, Berge-Henegouwen GP van, Kate FJW ten, Hop WCJ, Hoek EW van der, Kerbert MJ, Lijf HH van, Ouden JW den, Smit AM, Vries RA de, Zanten RAA van, Schalm SW. Triple therapy with ursodeoxycholic acid, prednisone and azathioprine in primary biliary cirrhosis: a 1-year randomized placebo-controlled study. J Hepatology 1998; 29: 736-42.

Wolkestorfer A, Laan MP, Savelkoul HF, Neijens HJ, Mulder PG, Oudesluys-Murphy AM, Sukhai RN, Oranje AP. Soluble E-selectin, other markers of inflammation and disease severity in children with atopic dermatitis. Br J Dermatol 1998; 138: 431-5.

Wolkestorfer A, Strobos MA, Glazenburg EJ, Mulder PG, Oranje AP. Fluticasone propionate 0.05% cream once daily versus clobetasone butyrate 0.05% cream twice daily in children with atopic dermatitis. J Am Dermatol 1998; 39: 226-31.

National scientific publications - Publications co-author

Dam QD van, Spijker A van 't, Arends LR, Hakkaart-van Roijen L, Donker MCH, Trijsburg RW. Doelmatigheid van psychotherapie: een haalbaarheidsonderzoek. Tijdschrift Psychotherapie 1998;24:5-22.

Dons IPM, Stiegelis HE, Voogd AC, Coebergh JWW, Crommelin MA, Roumen RRMH, Vreugdenhil G, Vingerhoets AJJM. Kwaliteit van leven na okselklierdissectie bij patienten met mammacarcinoom. Ned Tijdschr Heelkd 1998;7:189-94.

Giard RWM, Coebergh JWW, Casparie-van Velzen IJAMG. Sterke stijging van de detectiefrequentie van prostaatkanker in Nederland gedurende de periode 1990-1996. Ned Tijdschr Geneeskd 1998;142:1958-62.

Giard RWM, Coebergh JWW. De keerzijde van diagnostische ijver. Ned Tijdschr Geneeskd 1998;142:2187-91.

Ouden D van den, Hop WCJ, Schroder FH. Leeftijd als prognostische factor bij patienten met een niet-gemetastaseerd prostaatcarcinoom behandeld met radicale prostatectomie; een prospectief onderzoek. Ned Tijdschr Urologie 1998; 4: 70-6.

Ouden D van den, Hop WCJ, Kranse R, Schroder FH. Tumorcontrole bij patienten met klinisch niet-gemetastaseerd prostaatcarcinoom, behandeld met radicale prostatectomie: een prospectief onderzoek. Ned Tijdschr Geneesk 1998; 142: 349-54.

Slob AK, Steyvers CL, Lottman PEM, Hop WCJ, Werff ten Bosch JJ van der. Psychofysiologisch diagnostisch onderzoek bij 376 patienten met een erectiestoornis. Ned Tijdschr Geneeskd 1998; 142: 2348-51.

Visser O, Coebergh JWW, Otter R, Schouten LJ (eds.) Head and neck tumours in the Netherlands, 1989-1995. Utrecht: Netherlands Cancer Registry, 1998 (ISBN 90-72175-21-2)

Visser O, Coebergh JWW, Schouten LJ, Dijck JAAM van(eds.) Incidence of cancer in the Netherlands, 1995. Utrecht: Vereniging van Integrale Kankercentra, 1998 (ISBN 90-72175-22-0)

Voogd AC, Crommelin MA, Repelaer van Driel OJ, Tutein Nolthenius-Puylaert MCB, Vreugdenhil G, Coebergh JWW. Betekenis van steroidreceptoren voor de prognose en de hormonale behandeling van patienten met mammacarcinoom: een retrospectief onderzoek in Zuidoost Nederland. Ned Tijdschr Geneeskd 1998;142:1772-8.

Waard-van der Spek FB de, Bernsen JC, Mulder PGH, Kleij A van der, Berg A, Oranje AP. EMLA crème als lokaal analgeticum bij BMR-vaccinatie bij kinderen. Tijdschrift voor Jeugdgezondheidszorg 1998; 30: 9-10.

Zeeuw GR de, Kazemier G, Hop WCJ, Lange JF, Bonjer HJ. Laparosopische behandeling van appendicitis acuta: minder pijn en wondinfecties, maar langere operatietijd; een gerandomiseerd onderzoek. Ned Tijdschr Geneesk 1998; 142: 459-63