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Publications 1999

Epidemiology of diseases

1st author



Basic epidemiologic research

1st author



Clinical epidemiology

1st author



Epidemiology of diseases


J.C. de Groot
Consequences of cerebral white matter lesions. A longitudinal population-based MRI study.
(Co)promotor(es): Jolles J, Hofman A, Breteler MMB. Thesis EUR, 1999.

M.V. Joosse
Visual fields in strabismic suppression and amblyopia.
(Co)promotor(es): Jong PTVM de. Thesis EUR, 1999.

H.F. de Leeuw 
Determinants of cerebral white matter lesions. A longitudinal population-based MRI study.
(Co)promotor(es): Hofman A, Gijn J van, Breteler MMB. Thesis EUR, 1999.

C.T.M. van Rossum
Socioeconomic inequalities in cardiovascular disease in an ageing population.
(Co)promotor(es): Grobbee DE, Mackenbach JP, Mheen H van de. Thesis EUR, 1999.

K. Klipstein - Grobusch
Pro- and antioxidants and risk of atherosclerosis and coronary heart disease in the elderly.
(Co)promotor(es): Hofman A, Grobbee DE, Boeing H, Witteman JCM. Thesis EUR, 1999.

A. Molarius
Determinants of relative weight and body fat distribution in an international perspective.
(Co)promotor(es): Hofman A, Tuomilehto J, Seidell. Thesis EUR, 1999.

I.C.D. Westendorp
Estrogen, atherosclerosis and cardiovascular disease in women. Epidemiological studies on menopause and hormone replacement therapy.
(Co)promotor(es): Hofman A, Grobbee DE, Witteman JCM. Thesis EUR, 1999.

R.C.W. Wolfs
Changing views on open-angle glaucoma. The Rotterdam Study.
(Co)promotor(es): Jong PTVM de, Hofman A. Thesis EUR, 1999.

PUBLICATIONS 1st AUTHOR International scientific publications

Bakker SLM, de Leeuw FE, de Groot JC, Hofman A, Koudstaal PJ, Breteler MMB. Cerebral vasomotor reactivity and cerebral white matter lesions in the elderly. Neurology 1999;52:578-83.

Bom JG van der, Bots ML, Haverkate F, Meijer P, Hofman A, Grobbee DE, Kluft C. Fibrinolytic activity in peripheral atheroclerosis in the elderly. 
Thromb Haemost 1999;81:275-80.

Bots ML, Breteler MMB, van Kooten F, Haverkate F, Meijer P, Koudstaal PJ, Grobbee DE, Kluft C. Coagulation and fibrinolysis markers and risk of dementia. The Dutch vascular factors in dementia study. Haemostasis 1998;28:216-22 (Released June 1999).

Bots ML, Hoes AW, Hofman A, Witteman JCM, Grobbee DE. Cross-sectionally assessed carotid intima-media thickness relates to long-term risk of stroke, coronary heart disease and death as estimated by available risk functions. J Intern Med 1999;245:269-76.

Bots ML, Kooten F van, Breteler MMB, Slagboom PE, Hofman A, Haverkate F, Meijer P, Koudstaal PJ, Grobbee DE, Kluft C. Response to activated protein C in subjects with and without dementia. The Dutch vascular factors in dementia study.
Haemostasis 1998;28:209-15 (Released June 1999).

Bots ML, Launer LJ, Lindemans J, Hoes AW, Hofman A, Witteman JCM, Koudstaal PJ, Grobbee DE. Homocysteine and short-term risk of myocardial infarction and stroke in the elderly. The Rotterdam Study. Arch Intern Med 1999;159:38-44.

Breteler MMB, Bots ML, Ott A, Hofman A. Risk factors for vascular disease and dementia. Haemostasis 1998;28:167-73 (Released June 1999).

Breteler MMB, Ott A, Hofman A. The new epidemic: frequency of dementia in the Rotterdam Study. Haemostasis 1998;28:117-123 (Released June 1999).

Bruyne MC de, Hoes AW, Kors JA, Hofman A, Bemmel JH van, Grobbee DE. Prolonged QT interval predicts cardiac and all-cause mortality in the elderly: the Rotterdam Study.
Eur Heart J 1999;20:278-84.

Bruyne MC de, Kors JA, Hoes AW, Klootwijk P, Dekker JM, Hofman A, Bemmel JH van, Grobbee DE. Both decreased and increased heart rate variability on the standard 10-second electrocardiogram predict cardiac mortality in the elderly: the Rotterdam Study.
Am J Epidemiol 1999;150:1282-8.

Geleijnse JM, Launer LJ, Hofman A, Pols HAP, Witteman JCM. Tea flavonoids may protect against atherosclerosis. The Rotterdam Study. Arch Intern Med 1999;159:2170-4.

Hak AE, Stehouwer CDA, Bots ML, Polderman KH, Schalkwijk CG, Westendorp ICD, Hofman A, Witteman JCM. Associations of C-reactive protein with measures of obesity, insulin resistance, and subclinical atherosclerosis in healthy, middle-aged women. Arterioscler Thromb Vasc Biol 1999;19:1986-91.

Harhangi BS, Farrer MJ, Lincoln S, Bonifati V, Meco G, de Michele G, Brice A, Dürr A, Martinez M, Gasser Th, Bereznai B, Vaughan JR, Wood NW, Hardy J, Oostra BA, Breteler MMB, the French Parkinson's Disease Genetics Study Group, the Italian Parkinson Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease. The Ile93Met mutation in the ubiquitin carboxy-terminal-hydrolase-L1 gene is not observed in European cases with familial Parkinson's disease. Neuroscience Letters 1999;270:1-4.

Hoogen PCW van den, Popele NM van, Feskens EJM, Kuip DAM van der, Grobbee DE, Hofman A, Witteman JCM. Blood pressure and risk of myocardial infarction in elderly men and women: the Rotterdam Study. J Hypertens 1999;17:1373-8.

Houterman S, Verschuren WMM, Hofman A, Witteman JCM. Serum cholesterol is a risk factor for myocardial infarction in elderly men and women: the Rotterdam Study.
J Intern Med 1999;246:25-33.

Kalmijn S, Curb JD, Rodriguez BL, Yano K, Abbott RD. The association of body weight and anthropometry with mortality in elderly men: The Honolulu Heart Program.
Int J Obesity 1999;23:395-402.

Kalmijn S, Launer LJ, Lindemans J, Bots JL, Hofman A, Breteler MMB. Total homocysteine and cognitive decline in a community-based sample of elderly subjects: the Rotterdam Study. Am J Epidemiol 1999;150:283-9.

Kalmijn S, Oey PL, Wokke JHJ, Wieneke GH. Autonomic function in patients with hereditary motor and sensory neuropathy type I and Lambert-Eaton myathenic syndrome. Electromyogr Clin Neurophysiol 1999;39:349-53.

Klaver CCW, Ott A, Hofman A, Assink JJM, Breteler MMB, Jong PTVM de. Is age-related maculopathy associated with Alzheimer's disease? The Rotterdam Study.
Am J Epidemiol 1999;150:963-8.

Klipstein-Grobusch K, Geleijnse JM, Breeijen JH den, Boeing H, Hofman A, Grobbee DE, Witteman JCM. Dietary antioxidants and risk of myocardial infaction in the elderly. The Rotterdam Study. Am J Clin Nutr 1999;69:261-6.

Klipstein-Grobusch K, Grobbee DE, Breeijen JH den, Boeing H, Hofman A, Witteman JCM. Dietary iron and risk of myocardial infarction in the Rotterdam Study.
Am J Epidemiol 1999;149:421-8.

Klipstein-Grobusch K, Grobbee DE, Koster JF, Lindemans J, Boeing H, Hofman A, Witteman JCM. Serum caeruloplasmin as a coronary risk factor in the elderly: the Rotterdam Study. Br J Nutr 1999;81:139-44.

Klipstein-Grobusch K, Koster JF, Grobbee DE, Lindemans J, Boeing H, Hofman A, Witteman JCM. Serum ferritin and risk of myocardial infarction in the elderly.
Am J Clin Nutr 1999;69:1231-6.

Launer LJ, Andersen K, Dewey ME, et al. Rates and risk for Alzheimer's disease: EURODEM collaborative analysis. Neurology 1999;52:78-84.

Leeuw FE de, Groot JC de, Oudkerk M, Witteman JCM, Hofman A, Gijn J van, Breteler MMB. A follow-up study of blood pressure and cerebral white matter lesions. Ann Neurol 1999;46:827-33.

Mehta KM, Ott A, Kalmijn S, Slooter AJC, Duijn CM van, Hofman A, Breteler MMB. Head trauma and risk of Dementia and Alzheimer's Disease. The Rotterdam Study. Neurology 1999;53:1959-62.

Mennen LI, Maat MPM de, Meijer G, Zock P, Grobbee DE, Kok FJ, Kluft C, Schouten EG. Postprandial response of activated factor VII in elderly women depends on the R353Q polymorphism. Br J Nutr 1999;70:435-8.

Mosterd A, D'Agostino RB, Silbershatz H, Sytkowski PA, Kannel WB, Grobbee DE, Levy D. Trends in the prevalence of hypertension, antihypertensive therapy, and left ventricular hypertrophy from 1950 to 1989. N Engl J Med 1999;340:1221-7.

Mosterd A, Hoes AW, Bruijne MC, Deckers JW, Linker DT, Hofman A, Grobbee DE. Prevalence of heart failure and left ventricular dysfunction in the general population. The Rotterdam Study. Eur Heart J 1999;20:447-55.

Ott A, Stolk RP, Harskamp F van, Pols HAP, Hofman A, Breteler MMB. Diabetes mellitus and the risk of dementia. The Rotterdam Study. Neurology 1999;53:1937-42.

Ott A, Rossum CTM van, Harskamp F van, Mheen H van de, Hofman A, Breteler MMB. Education and the incidence of dementia in a large population-based study. The Rotterdam Study. Neurology 1999;52:663-6.

Peters HW, Westendorp ICD, Hak AE, Stehouwer CD, Hofman A, Witteman JCM. Menopausal status and risk factors for cardiovascular disease. J Intern Med 1999;246:521-8.

Pleumeekers HJCM, Gruijl A de, Hofman A, Beek AJ van, Hoes AW. Prevalence of aortic aneurysm in men with a history of inguinal hernia repair. Br J Surg 1999;86:1155-8.

Pleumeekers HJCM, Hoes AW, Hofman A, Urk H van, Does E van der, Grobbee DE. Selecting subjects for ultrasonographic screening for aneurysms of the abdominal aorta: four different strategies. Int J Epidemiol 1999;28:682-6.

Ramrattan R, Wolfs RCW, Hofman A, De Jong PTVM. Determinants of optic disk characteristics in a general population: The Rotterdam Study. Ophthalmology 1999;106:1588-96

Rossum CTM van, Mheen H van de, Breteler MMB, Grobbee DE, Mackenbach JP. Socioeconomic differences in stroke among Dutch elderly women: the Rotterdam Study. Stroke 1999;30:357-62.

Rossum CTM van, Mheen H van de, Witteman JCM, Mackenbach JP, Grobbee DE. Socioeconomic status and aortic atheroclerosis in Dutch elderly people: the Rotterdam Study. Am J Epidemiol 1999;150:142-8.

Vokó Z, Bots ML, Hofman A, Koudstaal PJ, Witteman JCM, Breteler MMB. J-shaped relation between blood pressure and stroke in treated hypertensives.
Hypertension 1999;34:1181-5.

Westendorp ICD, Bots ML, Grobbee DE, Reneman RS, Hoeks APG, Popele NM van, Hofman A, Witteman JCM. Menopausal status and distensibility of the common carotid artery. Arterioscler Thromb Vasc Biol 1999;19:713-7.

Westendorp ICD, Veld BA in `t, Bots ML, Akkerhuis JM, Hofman A, Grobbee DE, Witteman JCM. Hormone replacement therapy and intima-media thickness of the common carotid artery. The Rotterdam Study. Stroke 1999;30:2562-7.

Witthaus E, Ott A, Barendregt JJ, Breteler MMB, Bonneux L. Burden of mortality and morbidity from dementia. Alzheimer Dis Assoc Disord 1999;13:176-81.

Wolfs RCW, Ramrattan R, Hofman A, Jong PTVM de. Cup-to-disc ratio: ophthalmoscopy versus automated measurement in a general population: the Rotterdam Study. Ophthalmology 1999;106:1597-1601.

National scientific publications

Breteler MMB. Vaatziekten en de ziekte van Alzheimer, is er een link?
Hart Bulletin 1999;30:144-49.

Further scientific publications

Baker FM, Launer LJ, Breteler MMB, Hofman A. Ommoord district residents: prevalence and treatment of depression. Int Psychogeriatr 1999;11:385-97.

Bots ML, Breteler MMB. Risicofactoren. In: Limburg M, Hijdra A, Cools HJM, eds. Cerebrovasculaire aandoeningen. Bohn Stafleu Van Loghum, Houten/Diegem, 1999;43-62.

Breteler MMB, Ott A, Hofman A. Vascular disease and vascular risk factors and dementia. In: Mayeux R, Christen Y, eds. Epidemiology of Alzheimer's disease: from gene to prevention. Heidelberg, Germany, Springer-Verlag, 1999: page 79-86.

Bruyne MC de, Hoes AW, Grobbee DE. Prevalence and prognosis of electrocardiographic findings in the elderly. In: Chester E, ed. Clinical cardiology in the elderly. Armonk, New York, USA: Fitira Publ. Comp., 1999.

Kalmijn S, Launer LJ. Dietary intake and the risk of dementia and cognitive decline in population-based studies. In: Vellas B, Fitten LJ, eds. Research and practice in Alzheimer's disease, Volume 2. Springer Publishing Company, 1999: page 140-145.

Launer LJ, Fratiglioni L, Andersen K, Breteler MMB, Copeland RJM, Dartigues J-F, Lobo A, Martinez-Lage J, Soininen H, Hofman A, eds. Regional differences in the incidence of dementia in Europe: EURODEM  Collaborative Analyses. In: Iqbal K, Swaab DF, Winblad B, Wisniewski HM, eds. Alzheimer's disease and related disorders. Chicester, John Wiley & Sons Ltd, 1999: page 9-15.

Uiterwaal CSPM, Grobbee DE. Family history, development and mechanisms of hypertension. In: McCarthy R, Blizard DA, Chevalier RL, eds. Handbook of Hypertension. Development of the hypertensive phenotype: basic and clinical studies. Elsevier Science B.V., Amsterdam, The Netherlands, 1999, pp. 639-62.

PUBLICATIONS CO-AUTHOR International scientific publications

Abbas N, Ricard S, Bonifati V, de Michele G, Bouley S, Vaughan JR, Gasser T, Marconi R, Broussolle E, Brefel-Courbon C, Harhangi BS, Oostra BA, Fabrizio E, Pradier L, Wood NW, Filla A, Meco G, Denefle P, Agid Y, Brice A, Genetics Study Group t FPD, on Genetic Susceptibility in Parkinson's Disease t EC. A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. Hum Mol Genet 1999;8:567-74.

Andersen K, Launer LJ, Dewey ME, Letenneur L, Ott A, Copeland JR, Dartigues JF, Kragh-Sorensen P, Baldereschi M, Brayne C, Lobo A, Martinez-Lage JM, Stijnen T, Hofman A.

Gender differences in the incidence of AD and vascular dementia: The EURODEM Studies. EURODEM Incidence Research Group. Neurology 1999;53:1992-7.

Baan CA, Stolk RP, Witteman, JCM, Grobbee DE, Feskens EJM. Physical activity in elderly subjects with impaired glucose tolerance and newly diagnosed diabetes mellitus. Am J Epidemiol 1999;149:219-27.

Baan CA, Ruige JB, Stolk RP, Witteman JCM, Dekker JM, Heine RJ, Feskens EJ. Performance of a predictive model to identify undiagnosed diabetes in a healthy case setting. Diabetes Care 1999;22:213-9.

Cheng KH, Leung SL, Hoekman HW, Beekhuis WH, Mulder PG, Geerards AJ, Kijlstra A. Incidence of contact-lens-associated microbial keratitis and its related morbidity. Lancet 1999;354:181-5.

Elbaz A, Grigoletto F, Baldereschi M, Breteler MMB, Manubens-Bertran JM, Lopez-Pousa S, Dartigues JF, Alperovitch A, Tzourio C, Rocca WA. Familial aggregation of Parkinson's disease: a population based case-control study in Europe. EUROPARKINSON Study Group. Neurology 1999;52:1876-82.

Gorin MB, Breitner JCS, Jong PTVM de, Hageman GS, Klaver CCW, Kuehn M, Seddon JM. The genetics of age-related macular degeneration. Mol Vis 1999;5:29.

Hansson L, Lithell H, Skoog I, Baro F, Banki CM, Breteler MMB, Carbonin PU, Castaigne A, Correia M, Degaute JP, Elmfelt D, Engedal K, Farsang C, Ferro J, Hachinski V, Hofman A, James OF, Krisin E, Leeman M, Leeuw PW de, Leys D, Lobo A, Nordby G, Olofsson B, Zanchetti A. Study on cognition and prognosis in the elderly (SCOPE). Blood Press 1999;8:177-83.

Hunt SC, Geleijnse JM, Wu LL, Witteman JCM, Williams RR, Grobbee DE. Enhanced blood pressure response to mild sodium reduction in subjects with the 235T variant of the angiotensinogen gene. Am J Hypertens 1999;12:460-6.

Joosse MV, Simonsz HJ, van Minderhout EM, Mulder PG, de Jong PTVM.Quantitative visual fields under binocular viewing conditions in primary and consecutive divergent strabismus. Graefe's Arch Clin Exp Ophthalmol 1999;237:535-45.

Kleijn MJJ de, Bots ML, Bak AAA, Westendorp ICD, Planellas J, Coelingh Bennink HJT, Witteman JCM, Grobbee DE. Hormone replacement therapy in perimenopausal women and 2-year change of carotid intima-media thickness. Maturitas 1999;32:195-204.

Klungel OH, Stricker BHCh, Paes AHP, Seidell JC, Bakker A, Vokó Z, Breteler MMB, Boer A de. Excess stroke among hypertensive men and women attributable to undertreatment of hypertension. Stroke 1999;30:1312-8.

Kooten F van, Ciabattoni G, Koudstaal PJ, Grobbee DE, Kluft C, Patrono C. Increased thromboxane biosynthesis is associated with poststroke dementia. Stroke 1999;30:1542-7.

Le Saux O, Urban Z, Goring HH, Csiszar K, Pope FM, Richards A, Pasquali-Ronchetti I, Terry S, Bercovitch L, Lebwohl MG, Breuning M, van den Berg P, Kornet L, Ott J, Jong PTVM de, Bergen AAB, Boyd CD. Pseudoxanthoma elasticum maps to an 820-kb region of the p13.1 region  of chromosome 16. Genomics 1999;62:1-10

Mahaffey K, Harrington RA, Simoons ML, Granger CB, Graffagnino C, Alberts MJ,  Laskowitz DT, Miller JM, Sloan MA, Berdan LG, MacAulay CM, Lincoff AM, Deckers JW,  Topol EJ, Califf RM. Stroke in patients with acute coronary syndromes. Incidence and outcomes in the platelet glycoprotein IIb/IIIa in unstable angina: receptor suppression using integrilin therapy (PURSUIT) trial. Circulation 1999;99:2371-7.

McClure MW, Berkowitz SD, Sparapani R, Tuttle R, Kleiman NS, Berdan LG, Lincoff AM, Deckers JW, Diaz R, Karsch KR, Greteler D, Kitt M, Simoons M, Topol EJ, Califf RM, Harrington RA, for the PURSUIT Investigators. Clinical significance of thrombocytopenia during a non-st-elevation acute coronary syndrome. The platelet glycoprotein IIb/IIIa in unstable agina: receptor suppression using integrilin therapy (PURSUIT) trail experience. Circulation 1999;99:2892-900.

Prospective Studies Collaboration. Collaborative overview (`meta-analysis') of prospective observational studies of the associations of usual blood pressure and usual cholesterol levels with common causes of death: protocol for the second cycle of the prospective studies collaboration. J Cardiovasc Risk 1999;6:315-20.

Saz P, Launer LJ, Dia JL, De-la-Cimara C, Marcos G, Lobo A. Mortality and mental disorders in a Spanish elderly population. Int J Geriatr Psychiatry 1999;14:1031-8.

Sijens PE, Oudkerk M, de Leeuw FE, de Groot JC, Achten E, Heijboer R, Hofman A, Breteler MMB. 1H Chemical shift imaging of the human brain at age 60-90 years reveals metabolic differences between women and men. Magnetic Resonance in Medicine 1999;42:24-31.

Schurgers LJ, Geleijnse JM, Grobbee DE, Pols HAP, Hofman A, Witteman JCM, Vermeer C. Nutritional intake of vitamins K1 (phylloquinone) and K2 (menaquinone) in The Netherlands. J Nutr Environm Med 1999;9:115-22.

Simoons ML, Boersma E, Zwaan C van der, Deckers JW. The challenge of acute coronary syndromes. Lancet 1999;353:1-4.

Skoog I, Kalaria RN, Breteler MMB.Vascular factors and Alzheimer's disease.
Alzheimer Dis Assoc Disord 1999;13:S106-14.

Vijver LP van de, Weber C, Kardinaal AF, Grobbee DE, Princen HM, Poppel G van. Plasma coenzyme Q10 concentrations are not decreased in male patients with coronary atherosclerosis. Free Radic Res 1999;30:165-72.

Vijver LP van de, Kardinaal AF, Duyvenvoorde W van, Kruijssen DACM, Grobbee DE, Poppel G van, Princen HM. Oxidation of LDL and extent of peripheral atherosclerosis. Free Radic Res 1999;31:129-39.

Visser M, Launer LJ, Deurenberg P, Deeg DJH. Past and current smoking in relation to body fat distribution in elderly men and women. J Gerontol: Med Sci 1999;50:M293-8.

Willlekes C, Hoeks APG, Bots ML, Brands PJ, Willigers JM, Reneman RS. Evaluation of off-line automated intima-media thickness detection of the common carotid artery based on M-line signal processing. Ultrasound Med Biol 1999;25:57-64.

Yaffe K, Browner W, Cauley J, Launer LJ, Harris T. Bone mineral density and cognitive decline in postmenopausal women: an estrogen mediated association.
JAGS 1999;47:1176-82.

Further scientific publications

Jagger C, Andersen K, Breteler MMB, Copeland JRM, Dartigues J-F, Di Carlo A, Fratiglioni L, Lobo A, Schmidt R, Soininen H, Hofman A, Launer LJ for the EURODEM Research Group, eds. Prognosis with dementia: Results from a European collaborative analysis of population-based studies. In: Iqbal K, Swaab DF, Winblad B, Wisniewski HM, eds. Alzheimer's disease and related disorders. Chicester, John Wiley & Sons Ltd, 1999: page 39-44.

Tol J, Slooter AJC, van Duijn CM. Genetic Factors in early-onset and late-onset Alzheimer's disease. In: R Mayeux, Christen Y (eds); Epidemiology of Alzheimer's disease: from gene to prevention. Springer-Verlag, Berlin Heidelberg New York, 1999, 33-39.

Basic epidemiologic research


Bijkerk C
Genetic epidemiology of osteoarthritis. Studies of familial aggregation and candidate genes.
(Co)promotor(es): Hofman A, Duijn CM van, Slagboom PE. Thesis EUR,1999.

De Laet CEDH
Osteoporosis and fracture prevention: costs and effects modeled on the Rotterdam Study.
(Co)promotor(es): Pols HAP, Hofman A, Hout BA van. Thesis EUR,1999.

PUBLICATIONS 1st AUTHOR International scientific publications

Bijkerk C, Houwing-Duistermaat JJ, Valkenburg HA, Meulenbelt I, Hofman A, Breedveld FC, Pols HAP, Duijn CM van, Slagboom PE. Heritabilities of radiological osteoarthritis in peripheral joints and of disk degeneration of the spine. Arthr Rheum 1999;42:1729-1735.

Bijkerk, C, Houwing-Duistermaat, JJ, Valkenburg, HA, Meulenbelt, I, Hofman,

Burger H, Laet CEDH de, Weel AEAM, Hofman A, Pols HAP. Added value of bone mineral density in hip fracture risk scores. Bone 1999;25:369-374.

Duijn CM van, Cruts M, Theuns J, Gassen G van, Backhovens H, Broeck M van den, Wehnert A, Serneels S, Hofman A, Broeckhoven C van. Genetic association of the presenilin-1 regulatory region with early-onset Alzheimer's disease. Eur J Hum Genet 1999;7:806-807.

Duijn CM van. Hormone replacement therapy and Alzheimer's disease. Maturitas 1999;31:201-205.

Harhangi BS, Oostra BA, Heutink P, Duijn CM van, Hofman A, Breteler MMB.

N-acetyltransferase-2 polymorphism in Parkinson's Disease: the Rotterdam Study. J Neurol Neurosurg Psychiatry 1999;67:518-20.

Laet CEDH de, Hout BA van, Burger H, Weel AEAM, Hofman A, Pols HAP. Incremental cost of medical care after hip fracture and first vertebral fracture: the Rotterdam Study. Osteoporos Int 1999;10:66-72.

Laet CEDH de, Hout BA van, Burger H, Weel AEAM, Hofman A, Pols HAP Multinational, placebo-controlled, randomised trial of the effects of alendronate on bone density and fracture risk in postmenopausual women with low bone mass: results of the FOSIT Study. Osteoporos Int 1999;9:461-468.

Rheeder P, Stolk RP, Mosterd A, Pols HAP, Hofman A, Grobbee DE. Insulin resistance syndrome and left ventricular mass in an elderly population (The Rotterdam Study). Am J Cardiol 1999;84:233-236.

Roks G, Dermaut B, Heutink P, Julliams A, Backhovens H, Broeck M van de, Serneels S, Hofman A, Broeckhoven C van, Duijn CM van, Cruts M. Mutation screening of the tau gene in patients with early-onset Alzheimer's disease. Neurosci Lett 1999;277:137-9.

Samren EB, van Duijn CM, Christiaens CGML, Hofman A, Lindhout D. Anti-epileptic drug regimens and major congenital abnormalities in the offspring. Ann Neurol 1999; 46:739-746.

Slooter AJC, Bronzova J, Witteman JCM, Hofman A, Broeckhoven C van, Duijn CM van. Estrogen use and early-onset Alzheimer's disease: a population-based study. J Neurol Neurosurg Psychiatry 1999;67:779-81.

Slooter AJC, Cruts M, Ott A, Bots ML, Witteman JCM, Hofman A, Broeckhoven C van, Breteler MMB, Duijn CM van. The effect of APOE on dementia is not through atherosclerosis: the Rotterdam Study. Neurology 1999;53:1593-5.

Slooter AJC, Houwing-Duistermaatt JJ, Harskamp F van, Cruts M, Broeckhoven C van, Breteler MMB, Hofman A, Stijnen T, Duijn CM van. Apolipoprotrein E genotype and the progression of Alzheimer's disease: the Rotterdam Study. J Neurol 1999;246:304-308.

Tol J, Roks G, Slooter AJC, van Duijn CM. Genetic and environmental factors in Alzheimer's disease. Rev Neurol 1999;155:10-16.

Weel AEAM, Uitterlinden AG, Westendorp ICD, Burger H, Schuit SCE, Hofman A, Helmerhorst TJM, Leeuwen JPTM van, Pols HAP. Estrogen receptor polymorphism predicts the onset of natural and surgical menopause. J Clin Endocrinol Metab 1999;84:3146-3150.

Further scientific publications

Tol J, Slooter AJC, Duijn CM van. Genetic factors in early-onset and late-onset Alzheimer's disease. In: R Mayeux, Christen Y (eds); Epidemiology of Alzheimer's disease: from gene to prevention. Springer-Verlag, Berlin Heidelberg New York, 1999, 33-39.


Alperovitch A, Zerr I, Pocchiari M, Mitrova E, Pedro Cuesta J de, Hegyi I, Collins S, Kretzschmar H, Duijn CM van, Will RG. Codon 129 prion protein genotype and sporadic CreutzfeldtJakob disease. Lancet 1999;353:1673-1674.

Beld A van den, Huhhtaniemi IT, Pettersson KS, Pols HAP, Grobbee DE, Jong FH de, Lamberts SWJ. Luteinizing hormone and different genetic variants as indicators of frailty in healthy elderly men. J Clin Endocrinol Metab 1999;84:1334-1339.

Dermaut B, Cruts M, Slooter AJC, Gestel S van, Jonghe Ch de, Vanderstichele H, Vanmechelen E, Breteler MMB, Hofman A, Duijn CM van, Broeckhoven Ch van. The Glu318Gly substitution in presenilin 1 is not causally related to Alzheimer's disease. Am J Hum Genet 1999;64:290-2.

Houlden H, Rizzu P, Stevens M, Knijff P de, Duijn CM van, Swieten JC van, Heutink P, Perez-Tur J, Thomas V, Baker M, Morris H, Rossor M, Jannsen JC, Petersen RC, Dodd P, Dark F, Boeve B, Dickson D, Davies P, Pickering-Brown S, Mann D, Adamson J, Lynch T, Payami H, Poorkaj P, Bird TD, Schellenberg GD, Chadraverty S, Norton J, Morris FC, Goate A, Hutton M, Hardy J. Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations. Neurosci Lett 1999;260:193-195.

Lips P, Chapuy MC, Dawson-Hughes B, Pols HAP, Holock MF. An international comparison of serum 25-hydroxyvitamin D measurements. Osteoporos Int 1999;9:394-397.

Meulenbelt I, Bijkerk C, De Wildt SCM, Miedema HS, Breedveld FC, Pols HAP, Hofman A, Van Duijn CM, Slagboom PE. Haplotype analysis of three polymorphisms of the COL2A1 gene and associations with generalised radiological osteoarthritis. An Hum Genet 1999;63:303-400.

Rizzu P, van Swieten JC, Joosse M, Hasegawa M, Stevens M, Tibben A, Niermeijer MF, Hillebrand M, Ravid R, Oostra BA, Goedert M, Duijn CM van, Heutink P. High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands. Am J Hum Genet;1999:64:414-421.

Stuijvenberg M van, Beijeren E van, Wils NH, Derksen-Lubsen G, Duijn CM van, Moll HA. Characteristics of the initial seizure in familial in febrile seizures siblings. Arch Dis Child 1999;80:178-80.

Clinical epidemiology


Meijer WT
Peripheral arterial disease in the elderly
(Co)promotor(es): Hoes AW, Hunink MGM. Thesis EUR, 1999.

Post PN
Incidence and survival of prostate cancer since 1970
(Co)promotor(es): Hofman A, Schröder FH, Coebergh JWW. Thesis EUR, 1999.

Wiegersma PA
Longterm effects of preventive activities of youth healthcare for school children in the Netherlands
(Co)promotor(es): Zielhuis GA, Hofman A. Thesis Nijmegen 1999.

PUBLICATIONS 1st AUTHOR International scientific publications

Bosch JL, Graaf Y van der, Hunink MGM for the DIST study group. Health-related quality of life after angioplasty and stent placement in patients with iliac artery occlusive disease: results of a randomized controlled clinical trial. Circulation 1999; 99: 3155-3160.

Coebergh JWW, Janssen-Heijnen MLG, Post PN, Razenberg PPA. Serious co-morbidity among unselected cancer patients newly diagnosed in the southeastern Part of the Netherlands in 1993-1996. J Clin Epidemiol 1999;52:1131-36.

Coebergh JWW. Survival of cancer patients in Finland, 1955-1994. Acta Oncologica 1999;38:531-33. (Editorial)

Dieleman JP, Gyssens IC, Sturkenboom MCJM, Niesters HGM, Ende ME van der. Substituting nevirapine for protease inhibitors because of intolerance. AIDS 1999;13:1423-24.

Dieleman JP, Gyssens IC, Ende ME van der, Marie S de, Burger DM. Urological complaints in relation to indinavir plasma concentrations in HIV-infected patients. AIDS 1999;13:473-78.

Eland IA, Belton KJ, Grootheest AC van, Meiners AP, Rawlins MD, Stricker BHCh. Attitudinal survey of voluntary reporting of adverse drug reactions. Br J Clin Pharmacol 1999;48:623-27.

Eland IA, Dofferhoff AS, Vink R, Zondervan PE, Stricker BHCh. Colitis may be part of the antiepileptic drug hypersensitivity syndrome. Epilepsia 1999;40:1780-3.

Eland IA, Puijenbroek EP van, Sturkenboom MCJM, Wilson JHP, Stricker BHCh. Drug-associated pancreatitis: twenty-one years of spontaneous reporting in the Netherlands. Am J Gastroenterol 1999;94:2417-22.

Feenstra J, Grobbee DE, Remme WJ, Stricker BHCh. Drug-induced heart failure. J Am Coll Cardiol 1999;33:1152-62.

Feenstra J, Lubsen J, Grobbee DE, Stricker BHCh. Heart failure treatments: issues of safety versus issues of quality of life. Drug Saf 1999;20:1-7.

Hunink MGM, Kuntz KM, Fleischmann KE, Brady TJ. Noninvasive imaging for the diagnosis of coronary artery disease: focusing the development of new diagnostic technology. Ann Intern Med 1999;131:673-680.

Janssen-Heijnen ML, Damhuis RA, Klinkhamer PJ, Schipper RM, Coebergh JWW. Increased but low incidence and poor survival of malignant mesothelioma in the southeastern part of the Netherlands since 1970: a population-based study. Eur J Cancer Prev 1999;8:311-14.

Klauw MM van der, Goudsmit R, Halie MR, Veer MB van `t, Herings RMC, Wilson JHP, Stricker BHCh. A population-based case-cohort study of drug-associated agranulocytosis. Arch Int Med 1999;159:369-74.

Klauw MM van der, Stricker BHCh. Drug-induced neutropenias: now and then. Arch Int Med 1999;159:2745.

Klungel OH, Stricker BHCh, Paes AHP, Seidell JC, Bakker A, Voko Z, Breteler MMB, De Boer A. Excess stroke among hypertensive men and women attributable to undertreatment of hypertension. Stroke 1999;30:1312-18.

Linden PD van der, Lei J van de, Nab HW, Knol A, Stricker BHCh. Achilles tendinitis associated with fluoroquinolones. Br J Clin Pharmacol 1999;48:433-37.

Penning-van Beest FJA, Aben KK, Meegen E van, Man RA de, Wilson JHP, Stricker BHCh. Determination of serum liver tests during therapy with coumarin anticoagulants. J Hepatol 1999;31:778-9.

Penning-van Beest FJA, Rosendaal FR, Grobbee DE, Meegen E van, Stricker BHCh. Course of the international normalized ratio in response to oral vitamin K1 in patients overanticoagulated with phenprocoumon. Br J Haematol 1999;104:241-45.

Post PN, Kil PJM, Coebergh JWW. Trends in survival of prostate cancer in southeastern Netherlands, 1971-1989. Int J Cancer 1999;84:551-54.

Post PN, Kil PJM, Hendrikx AJM, Janssen-Heijnen MLG, Crommelin MA, Coebergh JWW. Co-morbidity in patients with prostate cancer and its relevance to treatment choice. Br J Urology 1999;84:652-56.

Post PN, Kil PJM, Hendrikx AJM, Poortmans Ph, Crommelin MA, Coebergh JWW. Trend and variation in treatment of localized prostate cancer in the southern part of the Netherlands, 1988-1996. Eur J Urol 1999;36:175-80.

Post PN, Stockton D, Davies TW, Coebergh JWW. Striking increase in incidence of prostate cancer in men aged < 60 years without improvement in prognosis. Br J Cancer 1999;79:13-17.

Post PN, Straatman H, Kiemeney LALM, Coebergh JWW. Increased risk of fatal prostate cancer may explain the rise in mortality in the Netherlands. Int J Epidemiol 1999;28:403-08.

Salas M, Hofman A, Stricker BHCh. Confounding by indication: an example of variation in the use of epidemiologic terminology. Am J Epidemiol 1999;149:981-83.

Sturkenboom MCJM, Jick S, Stricker BHCh. Minocycline and lupus-like syndrome in acne patients. Arch Int Med 1999;159:493-7.

National scientific publications

Coebergh JWW. Had brede oncologie gunstige resultaten? Een bevestigend antwoord aan de hand van een Europese vergelijking. In: Liber Amicorum Dr WPM Breed. Peters WG (red.) Eindhoven: Catharinaziekenhuis, 1999, blz 118-22.

Coebergh JWW. Crommeloncologie: meer dan sociale oncologie en kankerepidemiologie: de ontwikkeling van 1978 tot heden. (verslag van een Crommeloncoloog) In: Liber Amicorum M.A. Crommelin. Bruijnen C, Coebergh J, van der Ham W, Ribot J, Vosveld R (red.) Eindhoven: Catharina ziekenhuis, 1999, pp 40-44. 

Coebergh JWW. De staat van de Volksgezondheid in 2015: beeldvorming versus harde cijfers. Medisch Contact 1999;54:105-11.

Coebergh JWW. Zorg voor de volksgezondheid na de vliegtuigramp in de Bijlmermeer; de beladen nasleep. Ned Tijdschr Geneeskd 1999;143:2305-10.

Feenstra J, Veld BA in `t, Linden PD van de, Grobbee DE, Stricker BH. Risicofactoren voor sterfte onder gebruikers van ibopamine. Ned Tijdschr Geneeskd 1999;143:746-51.

Feenstra J, Veld BA in `t, Stricker BHCh. Bijwerkingen van cardiovasculaire geneesmiddelen in de huisartspraktijk: anti-arrhythmica. Hart Bulletin 1999;30:46-50.

Giard RWM, Coebergh JWW. Steeds geavanceerder detectie van lymfkliermetastasen: de problemen van stadiummigratie. Ned Tijdschr Geneeskd 1999;143:1766-71.

Kuper-Hommel MJJ, Vrints LW, Coebergh JWW, Vreugdenhil G. High grade primary malt-lymphoma of the breast: a case-study. Neth J Med 1999;54:235-38.

Stijnen T, Arends LR. Dwalingen in de methodologie. XVI. Wat te doen met ontbrekende waarnemingen? Ned Tijdschr Geneeskd. 1999;143:1996-2000.

Stricker BHCh, Veld BA in `t, Feenstra J. De noodzaak voor `postmarketing surveillance'.Ned Tijdschr Geneeskd 1999;143:711-13.

Veld BA in `t, Feenstra J, Stricker BHCh. Bijwerkingen van cardiovasculaire geneesmiddelen in de huisartspraktijk: antihypertensiva. Hart Bulletin 1999;30:14-17.

Veld BA in `t. Is combinatie van een SSRI-antidepressivum met een eetlustremmer verantwoord? Psychiatrie Vademecum, november 1999.


Alexander FE, Boyle P, Carli P.M., Coebergh JWW, Ekbom A, Levi F, McKinney PA, McWhirter W, Michaelis J, Peris-Bonet R, Petridou E, Pompe-Kirn V, Plesko I, Pukkela E, Rahu M, Stiller CA, Storm H, Terracini B, Vatten L, Wray N. Population Density and Childhood leukamia: results of the EUROCLUS Study. Eur J Cancer 1999;35:439-444

Bosch WA van den, Leenders I, Mulder PG. Topographic anatomy of the eyelids, and the effects of sex and age. Br J Ophthalmol 1999;83:347-52.

Brekelmans CT, Voogd AC, Botke G, Geel AN van, Rodrigus P, Rutgers EJTh, Klijn JGM, Coebergh JW for the Dutch Study Group on Local Recurrence after Breast Conservation (BORST). Family history of breast cancer and local recurrence after breast conserving therapy. Eur J Cancer 1999;35:620-26.

Brezinka C, Laudy JAM, Ursem NTC, Hop WCJ, Wladimiroff JW. Fetal pulmonary venous flow into the left atrium relative to diastolic and systolic cardiac time intervals. Ultrasound Obstet Gynecol 1999;13:191-195.

Briel JW, Stoker J, Rociu E, Lameris JS, Hop WCJ, Schouten WR. External anal sphincter atrophy on endoanal magnetic resonance imaging adversely affects continence after sphincteroplasty. Br J Surg 1999; 86:1322-1327.

Brink J van den, Weijtens O, Feron EJ, Mulder PG, Mertens DA, Peperkamp E, Ringens PJ, van Meurs JC. Follow-up of functionally lost eyes after vitrectomy and silicone oil tamponade for tractional retinal detachment.  Graefe's Arch Clin Exp Ophthalmol 1999;237:741-4.

Brouwer JT, Hansen BE, Niesters HG, Schalm SW. Early prediction of response in interferon monotherapy and in interferon-ribavirin combination therapy for chronic hepatitis C: HCV RNA at 4 weeks versus ALT. J Hepatol 1999 Feb;30:192-8.

Broek WW van den, Leentjens AF, Mulder PG, Kusuma A, Bruijn JA. Low-dose esmolol bolus reduces seizure duration during electroconvulsive therapy: a double-blind, placebo-controlled study. Br J Anaesth 1999;83:271-4.

Bruijn JA, Moleman P, Mulder PG, Broek WW van den. Depressed in-patients respond differently to imipramine and mirtazapine. Pharmacopsychiatry 1999;32:87-92.

Buyruk HM, Stam HJ, Snijders CJ, Lameris JS, Holland WP, Stijnen T. Measurement of sacroiliac joint stiffness in peripartum pelvic pain patients with Doppler imaging of vibrations (DIV). Eur J Obstet Gynecol Reprod Biol 1999;83:159-63.

Cartwright RA, Brincker H, Carli PM, Clayden D, Coebergh JWW, Jack A, McNally R, Morgan G, Sanjose S, Tumino R, Vornanen M. The rise in incidence of non-Hodgkin's lymphomas in Europe, 1985-1992. Eur J Cancer 1999;35:627-33.

Catsman-Berrevoets CE, Dongen HR van, Mulder PGH, Paz y Geuze D, Paquier PF, Lequin MH. Tumour type and size are high risk factors for the syndrome of ``cerebellar" mutism and subsequent dysarthria. J Neurol Neurosurg Psychiatry 1999:67:755-7.

Cobbaert C, Mulder PG, Baadenhuijsen H, Zwang L, Weykamp CW, Demacker PN. Survey of total error of precipitation and homogeneous HDL-cholesterol methods and simultaneous evaluation of lyophilized saccharose-containing candidate reference materials for HDL-cholesterol. Clin Chem 1999;45:360-70.

Cobben NA, Drent M, Jacobs JA, Schmitz MP, Mulder PG, Henderson RF, Wouters EF, van Dieijen-Visser MP. Relationship between enzymatic markers of pulmonary cell damage and cellular profile: a study in bronchoalveolar lavage fluid. Experimental Lung Research 1999;25:99-111.

Cobben NA, Drent M, Dieijen-Visser MP van, Mulder PG, Wouters EF, Henderson RF. Usefulness of monitoring beta-glucuronidase in pleural effusions. Clin Biochem 1999;32:653-8.

Cobben NAM, Jacobs JA, Dieijen-Visser MP van, Mulder PGH, Wouters EFM, Drent M. Diagnostic value of BAL fluid cellular profile and enzymes in infectious pulmonary disorders. Eur Resp J 1999;14:496-502.

Deinum J, Ronn B, Mathiesen E, Derkx FH, Hop WCJ, Schalekamp HA. Increase in serum prorenin precedes onset of microalbuminuria in patients with insulin-dependent diabetes mellitus. Diabetologica 1999;42:1006-1010.

Derksen PWB, Langerak AW, Kerkhof E, Wolvers-Tettero ILM, Boor PPC, Mulder AH, Vrints LW, Coebergh JWW, Krieken JHJM van, Schuuring E, Kluin PhM, Dongen JJM  van. Comparison of different PCR-based approaches for clonality assessment of immunoglobulin heavy chain gene rearrangements in B-cell neoplasia. Mod Pathol 1999;12:794-805.

Faber FWM, Klein-Rensink GJ, Verhoog MW, Vijn AH, Snijders CJ, Mulder PGH, Verhaar JAN.  Mobility of the first tarsometatarsal joint in relation to hallux valgus deformity: anatomical and biomechanical aspects. Foot Ankle Int 1999;20:651-6.

Ferdinand RF, Stijnen T, Verhulst FC, Reijden M van der. Associations between behavioural and emotional problems in adolescence and maladjustment in young adulthood. J Adolesc 1999;22:123-36.

Garcia Rodriguez LA, Duque A, Castellsague J, Perez-Gutthann S, Stricker BHCh. Br J Clin Pharmacol 1999;48:847-52.

Goldman L, Coxson P, Hunink MGM, Goldman PA, Tosteson ANA, Mittleman MA, Williams L, Weinstein MC. The relative influence of secondary versus primary prevention using the National Cholesterol Education Program Adult Treatment Panel II guidelines. J Am Coll Cardiol 1999 Sep;34(3):768-76.

Halteren van HK, Roumen RMH, Coebergh JWW, Croiset van Uchelen FAAM, Keuning JJ, Vreugdenhil G. The impact of 5-FU-based bolus chemotherapy on survival in patients with advanced colorectal cancer. Anticancer Research 1999;19:3447-50.

Hazelzet JA, Stubenitsky R, Petrov AB, Wieringen GW van, Voort E van der, Hess J, Hop WCJ, Thijs LG, Duncker DJ, Poolman JT, Verdouw PD. Cardiovascular aspects of experimental meningococcal sepsis in young and lder awake piglets age-related differences. Shock 1999;2:145-154.

Heisterkamp J, Bommel J van, Hop WCJ, Tilanus HW, Zondervan PE, IJzermans JNM. P53 overexpression in colorectal metastases confined to the liver and outcome of liver resection. Hepato-Gastroenterology 1999;46:3109-3114.

Herwaarden MA van, Samsom M, Nispen CH van, Mulder PG, Smout AJ. The effect of Helicobacter pylori eradication on intragastric pH during dosing with lansoprazole or ranitidine. Alimentary Pharmacology & Therapeutics 1999;13:731-40.

Heuvel OA van den, Mey WG de, Buddingh H, Bots ML. Use of maternal care in a rural area of Zimbabwe: a population-based study. Acta Obstet Gynecol Scand 1999;78:838-46.

Holm AF, Godthelp T, Fokkens WJ, M Severijnen EA, Mulder PG, Vroom TM, Rijntjes E. Long-term effects of corticosteroid nasal spray on nasal inflammatory cells in patients with perennial allergic rhinitis. Clin Exp Allergy 1999;29:1356-66.

Hoogstraten HJ van, Hansen BE, van Buuren HR, ten Kate FJ, van Berge-Henegouwen GP, Schalm SW. Prognostic factors and long-term effects of ursodeoxycholic acid on liver Biochemical parameters in patients with primary biliary cirrhosis. Dutch Multi-Centre PBC Study Group. J Hepatol 1999 Aug;31:256-62.

Houven van Oordt CW van der, Smits R, Schouten TG, Houwing-Duistermaat JJ, Williamson SL, Luz A, Meera, Khan P, van der Eb AJ, Breuer ML, Fodde R The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model. Genes Chromosomes Cancer 1999;24:191-8

Idu MM, Buth J, Hop WCJ, Cuypers P, Pavoordt ED van de, Tordoir JM. Factors influencing the development of vein-graft stenosis and their significance for clinical management. Eur J Vasc Endovasc Surg 1999;17:15-21.

Janssen HLA, Gerken G, Carreno V, Marcellin  P, Naoumov NV, Craxi A, Ring-Larsen H, Kitis G, Hattum J van, Vries RA de, Michielsen PF, Kate FJW ten, Hop WCJ, Heijtink RA, Honkoop P, Schalm SW. Interferon Alpha for chronis hepatitis B infection: increased efficacy of prolonged treatment. Hepatology 1999;30:238-243.

Janssens HM, Devadason SG, Hop WCJ, LeSouef PN, Jongste JC de, Tiddens HAWM. Variability of aerosol delivery via spacer devices in young asthmatic children in daily life. Eur Respir J 1999; 13: 787-791.

Jobsis Q, Schellekens SL, Kroesbergen A, Hop WCJ, Jongste JC de. Sampling of exhaled nitric oxide in children: end-expiratory plateau balloon and tidal breathing methods compared. Eur Respir J 1999; 13:1406-1410.

Joosten KF, Verhoeven JJ, Hop WCJ, Hazelzet JA. Indirect calometry in mechanically ventilated infants and children: accuracy of total daily energy expenditure with 2 hour measurements. Clin Nutrition 1999;18:149-152.

Kamphuis AGA, Engelen AD van, Tetteroo E, Hunink MGM, Mali WPTM for the DIST study group. Impact of different hemodynamic criteria for stent placement after suboptimal iliac angioplasty. JVIR 1999;10:741-746.

Kleinjan A, Dijkstra MD, Boks SS, Severijnen LA, Mulder PG, Fokkens WJ. Increase in IL-8, IL-10, IL-13, and RANTES mRNA levels (in situ hybridization) in the nasal mucosa after nasal allergen provocation. J Allergy Clin Immunol 1999;103:441-50.

Krijger RR de, van der Harst E, van der Ham F, Stijnen T, Dinjens WN, Koper JW, Bruining HA, Lamberts SW, Bosman FT. Prognostic value of p53, bcl-2, and c-erbB-2 protein expression in phaeochromocytomas. J Pathol. 1999;188:51-55.

Kroesbergen A, Jobsis Q, Bel EHD, Hop WCJ, Jongste JC de. Flow-dependency of exhaled nitric oxide in children with asthma and cystic fibrosis. Eur Respir J 1999;14: 871-875.

Kroon BBR, Bergman W, Coebergh JWW, Ruiter DJ on behalf of the Dutch Melanoma Working Party. Consensus on the management of malignant melanoma of the skin in the Netherlands. Melanoma Res 1999;9:207-12.

Kuntz KM, Fleischmann KE, Hunink MGM, Douglas PS. Cost-effectiveness of diagnostic strategies for patients with chest pain. Ann Intern Med 1999;130:709-718.

Lankeren W van, Gussenhoven EJ, Honkoop J, Stijnen T, Overhagen H van, Wittens CH, Kranendonk SE, Sambeek MR van, Lugt A van der. Plaque area increase and vascular remodeling contribute to lumen area change after percutaneous transluminal angioplasty of the femoropopliteal artery: an intravascular ultrasound study. J Vasc Surg 1999;29:430-41.

Laudy JA, Ursem NT, Mulder PG, Wladimiroff JW. Doppler velocimetry of normal human fetal venous intrapulmonary branches. Ultrasound Obstet Gynecol 1999;13:247-54.

Lequin MH, Rijn RR van, Robben SG, Hop WCJ, Dijkhuis S, Fijten MM, Meijer LA, Kuijk C van. Evaluation  of short-term precision for tibial ultrasonometry. Calcif Tissue Int 1999; 64:24-27.

Macklon NS, Laudy JA, Mulder PG, Wladimiroff JW. Behavior-state-dependent changes in human fetal pulmonary blood flow velocity waveforms. Obstet Gynecol 1999;93:184-8.Medici G, Mallios C, Custers WT, Meerbeek JP van, Verhoeven GT, Hop WCJ. Anesthesia for endobronchial laser surgery: a modified technique. Anesth Analg 1999;88:298-301.

Meer JB van der, Glazenburg EJ, Mulder PGH, Eggink HE, Coenraads PJ. The management of moderate to severe atopic dermatitis in adults with topical fluticasone propionate. Br J Dermatol 1999;140:1114-21.

Meijer RJ, Kerstjens HAM, Arends LR, Kauffman HF, Koëter GH, Postma DS. Effects of inhaled fluticasone and oral prednisolone on clinical and inflammatory parameters in patients with asthma. Thorax 1999;54:894-899.

Noord JA van, Schreurs AJ, Mol SJ, Mulder PG. Addition of salmeterol versus doubling the dose of fluticasone propionate in patients with mild to moderate asthma. Thorax 1999;54:207-12.

Nouwen JL, Wielenga JJ, Overhagen H van, Lameris JS, Kluytmans JA, Behrendt MD, Hop WC, Verbrugh HA, Marie S de. Hickman catheter-related infections in neutropenic patients: insertion in the operating theater versus insertion in the radiology suite. J Clin Oncol 1999 17:1304-1311.

Patandin S, Dagnelie PC, Mulder PG, Coul E op de, Veen JE van der, Weisglas-Kuperus N, Sauer PJ. Dietary exposure to polychlorinated biphenyls and dioxins from infancy until adulthood: a comparison between breast-feeding, toddler, and long-term exposure. Environmental Health Perspectives 1999;107:45-51.

Patandin S, Lanting CI, Mulder PG, Boersma ER, Sauer PJ, Weisglas-Kuperus N. Effects of environmental exposure to polychlorinated biphenyls and dioxins on cognitive abilities in Dutch children at 42 months of age. J Pediatr 1999;134:33-41.

Pinheiro PS, Heijden LH van der, Coebergh JWW. Unchanged survival of gastric cancer in the southeastern Netherlands since 1982: result of differential trends in incidence according to Lauren type and subsite. Int J Cancer 1999;84:28-32.

Rhee HJ van der, Spek-Keijser LMT van der, Westering R van, Coebergh JWW. Increase in and stabilization of incidence and mortality of primary cutaneous malignant melanoma in western Netherlands, 1980-95. Br J Dermat 1999;140:463-67.

Robben SGF, Lequin MH, Meradji M, Diepstraten AFM, Hop WCJ. Atrophy of the quadriceps muscle in children with a painful hip. Clin Physiology 1999;5:385-393.

Roodnat JI,  Zietse R, Mulder PG, Rischen-Vos J, van Gelder T, IJzermans JN, Weimar W. The vanishing importance of age in renal transplantation. Transplantation 1999;67:576-80.

Roodnat JI, Zietse R, Rischen-Vos J, Gelder T van, Mulder PG, IJzermans JN, Weimar W. Effect of race on kidney transplant survival in non-European recipients. Transplant Proc 1999;31:312-3.

Roodnat JI, Zietse R, Rischen-Vos J, van Gelder T, Mulder PG, IJzermans JN, Weimar W. Renal graft survival in native and non-native European recipients. Transplant International 1999:12:135-40.

Rooij J van, Schwartzenberg SG, Mulder PG, Baarsma SG. Oral vitamins C and E as additional treatment in patients with acute anterior uveitis: a randomised double masked study in 145 patients. Br J Ophthalmol 1999;83:1277-82.

Rossum TG van, Vulto AG, Hop WC, Schalm SW. Pharmacokinetics of intravenous glycyrrhizin after single and multiple doses in patients with chronic hepatitis C infection. Clin Ther 1999;21:2080-90.

Rossum TGJ van, Vulto AG, Hop WCJ, Brouwer JT, Niesters HGM, Schalm SW. Intravenous glycyrrhizin for the treatment of chronic hepatitis C: a double blind randomized placebo-controlled phase I/II trial. J Gastroenterology Hepatology 1999;14:1093-1099.

Sant M, Berrino F, Coebergh JWW. Reliable data on stage distribution are essential.Br Med J 1999;319:1572.

Sas TC, Cromme-Dijkhuis AH, Muinck Keizer-Schrama SM de, Stijnen T, Teunenbroek A van, Drop SL. The effects of long-term growth hormone treatment on cardiac left ventricular dimensions and blood pressure in girls with Turner's syndrome. Dutch Working Group on Growth Hormone. J Pediatr 1999;135:470-476.

Sas TC, Gerver WJ, Bruin R de, Stijnen T, Muinck Keizer-Schrama SM de, Cole TJ, Teunenbroek A van, Drop SL. Body proportions during long-term growth hormone treatment in girls with Turner syndrome participating in a randomized dose-response trial. J Clin Endocrinol Metab 1999;84:4622-8.

Sas TC, Muinck Keizer-Schrama SM de, Stijnen T, Jansen M, Otten BJ, Hoorweg-Nijman JJ, Vulsma T, Massa GG, Rouwe CW, Reeser HM, Gerver WJ, Gosen JJ, Rongen-Westerlaken C, Drop SL. Normalization of height in girls with Turner syndrome after long-term growth hormone treatment: results of a randomized dose-response trial. J Clin Endocrinol Metab 1999;84:4607-12.

Sas TCJ, Muinck Keizer-Schrama SMPF de, Stijnen T, Teunenbroek A van, Hokken-Koelega ACS, Waelkens JJJ, Massa GG, Vulsma T, Gerver WJ, Reeser HM, Delemarre-van de Waal HE, Jansen M, Drop SLS, and the Dutch Advisory Group on Growth Hormone. Final height in girls with Turner's syndrome treated with once or twice daily growth hormone injections. Arch Dis Child 1999;80:36-41.

Sas T, Waal W de, Mulder P, Houdijk M, Jansen M, Reeser M, Hokken-Koelega A. Growth hormone treatment in children with short stature born small for gestational age: 5-year results of a randomized, double-blind, dose-response trial. J Clin Endocrinol Metab 1999;84:3064-70.

Schalm SW, Weiland O, Hansen BE, Milella M, Lai MY, Hollander A, Michielsen PP, Bellobuono A, Chemello L, Pastore G, Chen DS, Brouwer JT. Interferon-ribavirin for chronic hepatitis C with and without cirrhosis: analysis of individual patient data of six controlled trials. Eurohep Study Group for Viral Hepatitis. Gastroenterology 1999;117:408-13.

Siersema PD, Hop WCJ, Blankenstein M van. Re: Risk of self-expanding metal stents in patients with prior radiation or chemotherapy. Gastr Endoscopy 1999;49:138-139.

Spronsen DJ van, Janssen-Heijnen MLG, Breed WPM, Coebergh JWW. Prevalence of co-morbidity and its relationship to treatment among patients with Hodgkin's disease and non-Hodgkin's lymphoma, 1993-1996. Ann Hematol 1999;78:315-19.

Teunenbroek A van, Muinck Keizer-Schrama SMPF de, Aanstoot HJ, Stijnen T, Hoogerbrugge N, Drop SLS, and the Dutch Working Group on Growth Hormone. Carbohydrate and lipid metabolism during various growth hormone dosing regimens in girls with Turner syndrome. Metabolism 1999;48:7-14.

Tiddens HA, Hofhuis W, Bogaard JM, Hop WCJ, Bruin H de, Willems LN, Jongste JC de. Compliance, hysteresis and collapsibility of human small airways. Am J Respir Crit Care 1999;160:1110-1118.

Ursem NT, Clark EB, Keller BB, Hop WC, Wladimiroff JW. Do heart rate and velocity variability derived from umbilical artery velocity waveforms change prior to clinical pregnancy-induced hypertension? Ultrasound Obstet Gynecol 1999;14:244-249.

Ursem NT, Clark EB, Keller BB, Hop WC, Wladimiroff JW. Assessment of fetal heart rate variability and velocity variability by Doppler velocimetry of the descending aorta at 10-20 weeks of gestation. Ultrasound Obstet Gynecol 1999;14:397-401.

Vermetten FA, Boermans AJ, Luiten WD, Mulder PG, Vermue NA. Comparison of salmeterol with beclomethasone in adult patients with mild persistent asthma who are already on low-dose inhaled steroids. J Asthma 1999;36:97-106.

Vlug, AE, Lei J van der, Mosseveld BMTh, Wijk MAM van, Linden PD van der, Sturkenboom MCJM, Bemmel JH van. Postmarketing surveillance based on electronic medical records: the IPCI project. Meth Inform Med 1999;38:339-344.

Voogd AC, Peterse JL, Crommelin MA, Rutgers EJTh, Botke G, Elkhuizen PHM, Geel AN van, Hoekstra CJM, Pel R van, Vijver MJ van de, Coebergh JWW and the Dutch Study Group on Local Recurrence after Breast Conservation (BORST). Histological determinants for different types of local recurrence after Breast-conserving therapy of invasive breast cancer. Eur J Cancer 1999;35:1828-37.

Voogd AC, Horst F van der, Beek MWP van, Crommelin MA, Peterse JL, Repelaer van Driel OJ, Coebergh JWW. The relationship between findings on the pre-treatment mammograms and local recurrence after breast-conserving therapy for invasive breast cancer. Eur J Surg Oncol 1999;25:273-79.

Voogd AC, Tienhoven GJ van, Peterse JL, Crommelin MA, Rutgers EJTh, Velde CJ van de, Geel AN van, Slot A, Rodrigus PT, Jobsen J, Meijenfeldt MF von, Coebergh JWW. Local recurrence after breast conservation therapy for early stage breast carcinoma. Detection, treatment and outcome in 266 patients. Cancer 1999;85:437-46.

Westerhof W, Nieuweboer-Krobotova L, Mulder PG, Glazenburg EJ. Left-right comparison study of the combination of fluticasone propionate and UV-A vs either fluticasone propionate or UV-A alone for the long-term treatment of vitiligo. Arch Dermatol 1999;135:1061-6.

Wijnhoven BPL, Siersema PD, Hop WCJ, Dekken H van, Tilanus HW. Adenocarcinomas of the distal oesophagus and gastric cardia are one clinical entity. Brit J Surgery 1999; 86:529-535.

Wolkestorfer A, Waard van der Spek FB de, Glazenburg EJ, Mulder PGH, Oranje AP. Scoring the severity of atopic dermatitis: three item severity score as a rough system for daily practice and as a pre-screening tool for studies. Acta Derm Venereol 1999;79:356-9.

Zweemer RP, Verheijen RH, Menko FH, Gille JJ, Diest PJ van, Coebergh JW, Shaw PA, Jacobs JJ, Kenemans P. Differences between hereditary and sporadic ovarian cancer. Eur J Obstet Gynecol Reprod Biol 1999;82:151-53.

National scientific publications

Bijl AM, Jong NW de, Mulder PG, Gerth van Wijk R, Groot H de. Prevalentie van IgE-gemedieerde allergie voor natuurrubberlatex op Rotterdamse operatiekamers. Ned Tijdschr Geneeskd 1999;143:1780-4.

Hoes AW, Mosterd A, Bouvy M, Grobbee DE. Een epidemie van hartfalen. De top is nog niet bereikt. Pharm Weekblad 1999;134:742-5.

Klijn AJ, Hop WCJ, Schroder FH, Bosch JLHR.  Bevredigende lange termijn resultaten van een sfincterprothese bij patienten met urine-incontinentie door deficientie van de intrinsieke urethrasfincter: onderzoek bij 86 patienten. Ned Tijdschr Geneesk 1999; 143: 352-355.

Kroon BBR, Bergman W, Coebergh JWW, Ruiter DJ. Consensus melanoom van de huid. Tijdschr Huisartsgeneeskd 1999;16:272-75.

Leer EM van, Coebergh JWW, Leeuwen FE  van. Trends in kankerincidentie en sterfte door kanker in Nederland: goed en slecht nieuws. Ned Tijdschr Geneeskd 1999;143:1502-06.

Martha I, Eland IA, van der Lei J, Quik RFP, Sturkenboom MCJM. Effect van medicamenteuze therapieduur op terugval in depressie en het zorgbeslag bij depressieve patienten behandeld met een antidepressivum. In: Huisarts, specialist en het elektronisch medisch dossier. 'EMD en kwaliteit'. Symposiumverslag EMD, Ede 1999

Moll van Charante AW, Mulder PGH. Verzuimpreventie door verzuimbegeleiding, bedrijfsartsgebonden effecten op begeleiding en nieuw verzuim. Tijdschr voor Bedrijfs- en Verzekeringsgeneeskd 1999;7:218-23.

Further scientific publications

Results, pp 73-523. (chapter 4)

Sant M, and the Eurocare Study Group. Overview of the Eurocare -2 results on survival of cancer patients diagnosed in 1985-1989, pp 525-41 (chapter 5). In: Berrino F, Capocaccia R, Esteve J, Gatta G, Hakulinen T, Micheli A, Sant M, Verdecchia A, (eds.). Survival of Cancer patients in Europe: the Eurocare II study. Lyon: IARC Scientific Publications No. 151, 1999.

Snijder S, Coebergh JWW, Otter R, Visser O, Schouten LJ. (eds.) Haematological malignancies in the Netherlands, 1989-1995. Utrecht: Netherlands Cancer Registry, 1999. (ISBN 90-72175-23-9).

Visser O, Schouten LJ, Dijck JAAM van, Coebergh JWW. Urological tumours in the Netherlands, 1989-1996. Utrecht: Netherlands Cancer Registry, 1999. (ISBN-90-72175-25-5).

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